Mus musculus      AGC/RSK


※ RSK family introduction

    RSK kinase is part of the mammalian target of rapamycin (mTOR) pathway which is a key regulator of cell growth via the regulation of protein synthesis. Both S6 kinase and eukaryotic initiation factor 4E-binding protein 1 (4EBP-1) are key mTOR effectors of cell growth. S6 kinase specifically phosphorylates ribosomal protein S6 in response to insulin or several classes of mitogens. S6 kinase is activated by Serine/Threonine phosphorylation and protein kinase C, and is inactivated by type 2A phosphatase. S6 kinase interacts with PPP1R9A/neurabin-1 (1).

Reference

1. InterPro Annotation: Ribosomal protein S6 kinase


There are 8 genes.  Reviewed (8 or Unreviewed (0

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Mum-0023
ENSMUSG00000003644.17
P18653
Rps6ka1; Mapkapk1a; Rsk1
2
iEKPD-Mum-0139
ENSMUSG00000023809.9
Q9WUT3
Rps6ka2; Mapkapk1c; Rsk3
3
iEKPD-Mum-0274
ENSMUSG00000031309.15
P18654
Rps6ka3; Mapkapk1b; Rps6ka-rs1; Rsk2
4
iEKPD-Mum-0165
ENSMUSG00000024952.12
Q9Z2B9
Rps6ka4; Msk2
5
iEKPD-Mum-0107
ENSMUSG00000021180.9
Q8C050
Rps6ka5; Msk1
6
iEKPD-Mum-0173
ENSMUSG00000025665.16
Q7TPS0
Rps6ka6
7
iEKPD-Mum-0091
ENSMUSG00000020516.15
Q8BSK8
Rps6kb1
8
iEKPD-Mum-0161
ENSMUSG00000024830.16
Q9Z1M4
Rps6kb2