Oryctolagus cuniculus      AGC/RSK


※ RSK family introduction

    RSK kinase is part of the mammalian target of rapamycin (mTOR) pathway which is a key regulator of cell growth via the regulation of protein synthesis. Both S6 kinase and eukaryotic initiation factor 4E-binding protein 1 (4EBP-1) are key mTOR effectors of cell growth. S6 kinase specifically phosphorylates ribosomal protein S6 in response to insulin or several classes of mitogens. S6 kinase is activated by Serine/Threonine phosphorylation and protein kinase C, and is inactivated by type 2A phosphatase. S6 kinase interacts with PPP1R9A/neurabin-1 (1).

Reference

1. InterPro Annotation: Ribosomal protein S6 kinase


There are 4 genes.  Reviewed (0 or Unreviewed (4

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Orc-0224
ENSOCUG00000010887.3
G1U4N1
RPS6KA1
2
iEKPD-Orc-0050
ENSOCUG00000002740.3
G1SI78
RPS6KA2
3
iEKPD-Orc-0122
ENSOCUG00000006428.2
G1SQZ7
RPS6KA6
4
iEKPD-Orc-0090
ENSOCUG00000004600.2
G1SM45
RPS6KB1