※ RSK family introduction

    RSK kinase is part of the mammalian target of rapamycin (mTOR) pathway which is a key regulator of cell growth via the regulation of protein synthesis. Both S6 kinase and eukaryotic initiation factor 4E-binding protein 1 (4EBP-1) are key mTOR effectors of cell growth. S6 kinase specifically phosphorylates ribosomal protein S6 in response to insulin or several classes of mitogens. S6 kinase is activated by Serine/Threonine phosphorylation and protein kinase C, and is inactivated by type 2A phosphatase. S6 kinase interacts with PPP1R9A/neurabin-1 (1).

Reference

1. InterPro Annotation: Ribosomal protein S6 kinase

  Reviewed (0)  or Unreviewed (6) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Otg-0088	ENSOGAG00000003977.2	H0WNW3	RPS6KA1
2		iEKPD-Otg-0184	ENSOGAG00000008184.2	H0WXW9	RPS6KA3
3		iEKPD-Otg-0156	ENSOGAG00000007168.2	H0WVS0	RPS6KA4
4		iEKPD-Otg-0210	ENSOGAG00000008981.2	H0WZM2	RPS6KA6
5		iEKPD-Otg-0170	ENSOGAG00000007813.2	H0WX39	RPS6KB1
6		iEKPD-Otg-0252	ENSOGAG00000010658.2	H0X362	RPS6KB2