※ RSK family introduction

    RSK kinase is part of the mammalian target of rapamycin (mTOR) pathway which is a key regulator of cell growth via the regulation of protein synthesis. Both S6 kinase and eukaryotic initiation factor 4E-binding protein 1 (4EBP-1) are key mTOR effectors of cell growth. S6 kinase specifically phosphorylates ribosomal protein S6 in response to insulin or several classes of mitogens. S6 kinase is activated by Serine/Threonine phosphorylation and protein kinase C, and is inactivated by type 2A phosphatase. S6 kinase interacts with PPP1R9A/neurabin-1 (1).

Reference

1. InterPro Annotation: Ribosomal protein S6 kinase

  Reviewed (0)  or Unreviewed (14) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Php-0461	PP1S316_74V6
2		iEKPD-Php-0190	PP1S174_62V6	Q6BCU1	PHOTA1
3		iEKPD-Php-0201	PP1S179_27V6	Q6BCU0	PHOTA2
4		iEKPD-Php-0741	PP1S75_230V6	A9SGB9	PHOTA3
5		iEKPD-Php-0765	PP1S84_194V6	Q6BCT8	PHOTB1
6		iEKPD-Php-0635	PP1S509_6V6	Q6BCT7	PHOTB2
7		iEKPD-Php-0711	PP1S66_253V6	A9SCZ7	PHYPADRAFT_127656
8		iEKPD-Php-0632	PP1S4_386V6	A9REJ9	PHYPADRAFT_174181
9		iEKPD-Php-0045	PP1S118_230V6	A9SU22	PHYPADRAFT_188412
10		iEKPD-Php-0084	PP1S131_94V6	A9SX38	PHYPADRAFT_189322
11		iEKPD-Php-0460	PP1S316_69V6	A9TTR4	PHYPADRAFT_2411
12		iEKPD-Php-0317	PP1S224_73V6	A9TGB3	PHYPADRAFT_2484
13		iEKPD-Php-0205	PP1S17_314V6	A9RMS5	PHYPADRAFT_68196
14		iEKPD-Php-0673	PP1S59_175V6	A9SA10	PHYPADRAFT_76512