Rattus norvegicus      AGC/RSK


※ RSK family introduction

    RSK kinase is part of the mammalian target of rapamycin (mTOR) pathway which is a key regulator of cell growth via the regulation of protein synthesis. Both S6 kinase and eukaryotic initiation factor 4E-binding protein 1 (4EBP-1) are key mTOR effectors of cell growth. S6 kinase specifically phosphorylates ribosomal protein S6 in response to insulin or several classes of mitogens. S6 kinase is activated by Serine/Threonine phosphorylation and protein kinase C, and is inactivated by type 2A phosphatase. S6 kinase interacts with PPP1R9A/neurabin-1 (1).

Reference

1. InterPro Annotation: Ribosomal protein S6 kinase


There are 6 genes.  Reviewed (2 or Unreviewed (4

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Ran-0428
ENSRNOG00000042411.3
Q63531
Rps6ka1
2
iEKPD-Ran-0058
ENSRNOG00000003919.5
P67999
Rps6kb1
3
iEKPD-Ran-0109
ENSRNOG00000006632.7
D3Z8E0
Rps6ka3
4
iEKPD-Ran-0338
ENSRNOG00000021117.7
D3ZSB7
Rps6ka4
5
iEKPD-Ran-0044
ENSRNOG00000002592.7
F1LYL8
Rps6ka6
6
iEKPD-Ran-0342
ENSRNOG00000021689.5
D4AE24
Rps6kb2