※ RSK family introduction

    RSK kinase is part of the mammalian target of rapamycin (mTOR) pathway which is a key regulator of cell growth via the regulation of protein synthesis. Both S6 kinase and eukaryotic initiation factor 4E-binding protein 1 (4EBP-1) are key mTOR effectors of cell growth. S6 kinase specifically phosphorylates ribosomal protein S6 in response to insulin or several classes of mitogens. S6 kinase is activated by Serine/Threonine phosphorylation and protein kinase C, and is inactivated by type 2A phosphatase. S6 kinase interacts with PPP1R9A/neurabin-1 (1).

Reference

1. InterPro Annotation: Ribosomal protein S6 kinase

  Reviewed (0)  or Unreviewed (6) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sus-0055	ENSSSCG00000003558.3	A0A287BHE2	RPS6KA1
2		iEKPD-Sus-0211	ENSSSCG00000012163.4	A0A287A3K5	RPS6KA3
3		iEKPD-Sus-0378	ENSSSCG00000028806.2	I3LS09	RPS6KA4
4		iEKPD-Sus-0216	ENSSSCG00000012456.4	F1S1R0	RPS6KA6
5		iEKPD-Sus-0306	ENSSSCG00000017670.3	F1S224	RPS6KB1
6		iEKPD-Sus-0223	ENSSSCG00000012910.3	A0A286ZRY0	RPS6KB2