※ RSK family introduction

    RSK kinase is part of the mammalian target of rapamycin (mTOR) pathway which is a key regulator of cell growth via the regulation of protein synthesis. Both S6 kinase and eukaryotic initiation factor 4E-binding protein 1 (4EBP-1) are key mTOR effectors of cell growth. S6 kinase specifically phosphorylates ribosomal protein S6 in response to insulin or several classes of mitogens. S6 kinase is activated by Serine/Threonine phosphorylation and protein kinase C, and is inactivated by type 2A phosphatase. S6 kinase interacts with PPP1R9A/neurabin-1 (1).

Reference

1. InterPro Annotation: Ribosomal protein S6 kinase

  Reviewed (0)  or Unreviewed (6) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Tag-0037	ENSTGUG00000001002.1	H0YRY6	RPS6KA1
2		iEKPD-Tag-0292	ENSTGUG00000009488.1	H0ZGV8	RPS6KA2
3		iEKPD-Tag-0239	ENSTGUG00000007471.1	H0ZAY2	RPS6KA3
4		iEKPD-Tag-0246	ENSTGUG00000007657.1	H0ZBF2	RPS6KB1
5		iEKPD-Tag-0530	ENSTGUG00000017085.1	H1A3C1	RPS6KB1
6		iEKPD-Tag-0197	ENSTGUG00000006119.1	H0Z6W0	RPS6KB2