※ FCP family introduction

    FCP/SCP phosphatase belongs to a family of phosphatase which uses an Asp nucleophile for catalysis. FCP/SCP is characterized by its phosphatase activity towards the CTD of the largest subunit of RNA polymerase II (1). At least seven members have been identified in human genome and FCP/SCP phosphatases share a conserved catalytic signature, which is known as DXDXT/V (2). Family member FCP1 is conserved among all eukaryotes and plays an important role in cell survival in budding and fission yeasts. SCP1 preferentially dephosphorylates Ser5 in CTD domain of RNA polymerase II and plays a role in the regulation of gene expression by controlling the transition from initiation/capping to processive transcript elongation (3). In addition, SCP1 also acts as a key regulator that functions in silencing neuronal gene expression (4).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Moorhead, G.B., Trinkle-Mulcahy, L. and Ulke-Lemee, A. (2007) Emerging roles of nuclear protein phosphatases. Nat Rev Mol Cell Biol, 8, 234-244. PMID: 17318227
3. Yeo, M., Lin, P.S., Dahmus, M.E. and Gill, G.N. (2003) A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. J Biol Chem, 278, 26078-26085. PMID: 12721286
4. Yeo, M., Lee, S.K., Lee, B., Ruiz, E.C., Pfaff, S.L. and Gill, G.N. (2005) Small CTD phosphatases function in silencing neuronal gene expression. Science, 307, 596-600. PMID: 15681389

  Reviewed (6)  or Unreviewed (17) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Art-1083	AT4G06599	Q8W3M6	At4g06599
2		iEKPD-Art-1103	AT4G21670	Q5YDB6	CPL1
3		iEKPD-Art-1086	AT5G01270	Q5YDB5	CPL2
4		iEKPD-Art-1545	AT2G33540	Q8LL04	CPL3
5		iEKPD-Art-1544	AT5G58003	Q00IB6	CPL4
6		iEKPD-Art-1073	AT1G55900	Q8VYE2	TIM50
7		iEKPD-Art-1071	AT1G20320	Q9LN24	At1g20320
8		iEKPD-Art-1065	AT1G43600	Q3E7I8	At1g43600
9		iEKPD-Art-1068	AT1G43610	Q3ECX9	At1g43610
10		iEKPD-Art-1069	AT2G02290	Q9ZVR2	At2g02290
11		iEKPD-Art-1067	AT2G04930	Q9SI33	At2g04930
12		iEKPD-Art-1084	AT2G36540	Q9SJQ4	At2g36540
13		iEKPD-Art-1064	AT3G17550	Q9LUP3	At3g17550
14		iEKPD-Art-1075	AT3G19595	Q9LJN7	At3g19595
15		iEKPD-Art-1079	AT5G23470	Q9FHL1	At5g23470
16		iEKPD-Art-1070	AT1G29770	Q9FXF4	CELLULOSE SYNTHASE LIKE D1
17		iEKPD-Art-1059	AT1G29780	A2RVS1	CELLULOSE SYNTHASE LIKE D5
18		iEKPD-Art-1077	AT3G55960	Q9LY49	F27K19_140
19		iEKPD-Art-1061	AT5G54210	Q9FL74	MDK4.3
20		iEKPD-Art-1063	AT5G45700	Q9FK73	MRA19.9
21		iEKPD-Art-1056	AT5G11860	Q9LYI7	SCP1-like small phosphatase 5
22		iEKPD-Art-1066	AT5G46410	F4KHG9	SSP4
23		iEKPD-Art-1072	AT4G18140	F4JQR6	SSP4b