Equus caballus      Asp-Based PSP/FCP


※ FCP family introduction

    FCP/SCP phosphatase belongs to a family of phosphatase which uses an Asp nucleophile for catalysis. FCP/SCP is characterized by its phosphatase activity towards the CTD of the largest subunit of RNA polymerase II (1). At least seven members have been identified in human genome and FCP/SCP phosphatases share a conserved catalytic signature, which is known as DXDXT/V (2). Family member FCP1 is conserved among all eukaryotes and plays an important role in cell survival in budding and fission yeasts. SCP1 preferentially dephosphorylates Ser5 in CTD domain of RNA polymerase II and plays a role in the regulation of gene expression by controlling the transition from initiation/capping to processive transcript elongation (3). In addition, SCP1 also acts as a key regulator that functions in silencing neuronal gene expression (4).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Moorhead, G.B., Trinkle-Mulcahy, L. and Ulke-Lemee, A. (2007) Emerging roles of nuclear protein phosphatases. Nat Rev Mol Cell Biol, 8, 234-244. PMID: 17318227
3. Yeo, M., Lin, P.S., Dahmus, M.E. and Gill, G.N. (2003) A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. J Biol Chem, 278, 26078-26085. PMID: 12721286
4. Yeo, M., Lee, S.K., Lee, B., Ruiz, E.C., Pfaff, S.L. and Gill, G.N. (2005) Small CTD phosphatases function in silencing neuronal gene expression. Science, 307, 596-600. PMID: 15681389


There are 8 genes.  Reviewed (0 or Unreviewed (8

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Eqc-0491
ENSECAG00000006787.1
F7DJD3
CTDNEP1
2
iEKPD-Eqc-1241
ENSECAG00000021835.1
F6WRF7
CTDP1
3
iEKPD-Eqc-0497
ENSECAG00000008950.1
F6Q9M8
CTDSP1
4
iEKPD-Eqc-0493
ENSECAG00000018788.1
F7A4N8
CTDSP2
5
iEKPD-Eqc-0489
ENSECAG00000023827.1
F6Y2U1
CTDSPL
6
iEKPD-Eqc-0498
ENSECAG00000011865.1
F6SE37
CTDSPL2
7
iEKPD-Eqc-0495
ENSECAG00000001235.1
F6W8S4
TIMM50
8
iEKPD-Eqc-0496
ENSECAG00000019228.1
F7BKH3
UBLCP1