※ FCP family introduction

    FCP/SCP phosphatase belongs to a family of phosphatase which uses an Asp nucleophile for catalysis. FCP/SCP is characterized by its phosphatase activity towards the CTD of the largest subunit of RNA polymerase II (1). At least seven members have been identified in human genome and FCP/SCP phosphatases share a conserved catalytic signature, which is known as DXDXT/V (2). Family member FCP1 is conserved among all eukaryotes and plays an important role in cell survival in budding and fission yeasts. SCP1 preferentially dephosphorylates Ser5 in CTD domain of RNA polymerase II and plays a role in the regulation of gene expression by controlling the transition from initiation/capping to processive transcript elongation (3). In addition, SCP1 also acts as a key regulator that functions in silencing neuronal gene expression (4).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Moorhead, G.B., Trinkle-Mulcahy, L. and Ulke-Lemee, A. (2007) Emerging roles of nuclear protein phosphatases. Nat Rev Mol Cell Biol, 8, 234-244. PMID: 17318227
3. Yeo, M., Lin, P.S., Dahmus, M.E. and Gill, G.N. (2003) A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. J Biol Chem, 278, 26078-26085. PMID: 12721286
4. Yeo, M., Lee, S.K., Lee, B., Ruiz, E.C., Pfaff, S.L. and Gill, G.N. (2005) Small CTD phosphatases function in silencing neuronal gene expression. Science, 307, 596-600. PMID: 15681389

  Reviewed (0)  or Unreviewed (16) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Mae-1546	MANES_02G056200	A0A2C9WBA2	MANES_02G056200
2		iEKPD-Mae-1565	MANES_03G140200	A0A2C9W8V5	MANES_03G140200
3		iEKPD-Mae-2097	MANES_06G019000	A0A2C9VM11	MANES_06G019000
4		iEKPD-Mae-1592	MANES_07G021300	A0A2C9VHR1	MANES_07G021300
5		iEKPD-Mae-1599	MANES_07G129900	A0A2C9VN20	MANES_07G129900
6		iEKPD-Mae-2098	MANES_08G068000	A0A251KBP2	MANES_08G068000
7		iEKPD-Mae-1619	MANES_09G104300	A0A251KLR4	MANES_09G104300
8		iEKPD-Mae-2099	MANES_09G186500	A0A2C9VC11	MANES_09G186500
9		iEKPD-Mae-1628	MANES_10G012000	A0A2C9V3V8	MANES_10G012000
10		iEKPD-Mae-1647	MANES_12G011700	A0A251JKH3	MANES_12G011700
11		iEKPD-Mae-1678	MANES_15G117300	A0A2C9UF15	MANES_15G117300
12		iEKPD-Mae-1682	MANES_16G025300	A0A2C9U855	MANES_16G025300
13		iEKPD-Mae-1683	MANES_16G043800	A0A2C9U8R2	MANES_16G043800
14		iEKPD-Mae-1693	MANES_17G043100	A0A2C9U6H7	MANES_17G043100
15		iEKPD-Mae-1694	MANES_17G061000	A0A2C9U734	MANES_17G061000
16		iEKPD-Mae-1695	MANES_17G065100	A0A251IUV1	MANES_17G065100