Ovis aries      Asp-Based PSP/FCP


※ FCP family introduction

    FCP/SCP phosphatase belongs to a family of phosphatase which uses an Asp nucleophile for catalysis. FCP/SCP is characterized by its phosphatase activity towards the CTD of the largest subunit of RNA polymerase II (1). At least seven members have been identified in human genome and FCP/SCP phosphatases share a conserved catalytic signature, which is known as DXDXT/V (2). Family member FCP1 is conserved among all eukaryotes and plays an important role in cell survival in budding and fission yeasts. SCP1 preferentially dephosphorylates Ser5 in CTD domain of RNA polymerase II and plays a role in the regulation of gene expression by controlling the transition from initiation/capping to processive transcript elongation (3). In addition, SCP1 also acts as a key regulator that functions in silencing neuronal gene expression (4).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Moorhead, G.B., Trinkle-Mulcahy, L. and Ulke-Lemee, A. (2007) Emerging roles of nuclear protein phosphatases. Nat Rev Mol Cell Biol, 8, 234-244. PMID: 17318227
3. Yeo, M., Lin, P.S., Dahmus, M.E. and Gill, G.N. (2003) A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. J Biol Chem, 278, 26078-26085. PMID: 12721286
4. Yeo, M., Lee, S.K., Lee, B., Ruiz, E.C., Pfaff, S.L. and Gill, G.N. (2005) Small CTD phosphatases function in silencing neuronal gene expression. Science, 307, 596-600. PMID: 15681389


There are 8 genes.  Reviewed (0 or Unreviewed (8

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Ova-0574
ENSOARG00000011121.1
W5PN95
CTDNEP1
2
iEKPD-Ova-0522
ENSOARG00000004163.1
W5P213
CTDP1
3
iEKPD-Ova-0633
ENSOARG00000019557.1
W5QE57
CTDSP1
4
iEKPD-Ova-0526
ENSOARG00000004836.1
W5P431
CTDSP2
5
iEKPD-Ova-0497
ENSOARG00000000638.1
W5NR60
CTDSPL
6
iEKPD-Ova-0516
ENSOARG00000003621.1
W5P0B9
CTDSPL2
7
iEKPD-Ova-0534
ENSOARG00000006227.1
W5P8B3
TIMM50
8
iEKPD-Ova-0588
ENSOARG00000013061.1
W5PU58
UBLCP1