※ FCP family introduction

    FCP/SCP phosphatase belongs to a family of phosphatase which uses an Asp nucleophile for catalysis. FCP/SCP is characterized by its phosphatase activity towards the CTD of the largest subunit of RNA polymerase II (1). At least seven members have been identified in human genome and FCP/SCP phosphatases share a conserved catalytic signature, which is known as DXDXT/V (2). Family member FCP1 is conserved among all eukaryotes and plays an important role in cell survival in budding and fission yeasts. SCP1 preferentially dephosphorylates Ser5 in CTD domain of RNA polymerase II and plays a role in the regulation of gene expression by controlling the transition from initiation/capping to processive transcript elongation (3). In addition, SCP1 also acts as a key regulator that functions in silencing neuronal gene expression (4).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Moorhead, G.B., Trinkle-Mulcahy, L. and Ulke-Lemee, A. (2007) Emerging roles of nuclear protein phosphatases. Nat Rev Mol Cell Biol, 8, 234-244. PMID: 17318227
3. Yeo, M., Lin, P.S., Dahmus, M.E. and Gill, G.N. (2003) A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. J Biol Chem, 278, 26078-26085. PMID: 12721286
4. Yeo, M., Lee, S.K., Lee, B., Ruiz, E.C., Pfaff, S.L. and Gill, G.N. (2005) Small CTD phosphatases function in silencing neuronal gene expression. Science, 307, 596-600. PMID: 15681389

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sem-1226	SELMODRAFT_103542	D8RWT2	SELMODRAFT_103542
2		iEKPD-Sem-1257	SELMODRAFT_108059	D8S403	SELMODRAFT_108059
3		iEKPD-Sem-1252	SELMODRAFT_111225	D8S8Q6	SELMODRAFT_111225
4		iEKPD-Sem-1261	SELMODRAFT_111624	D8S8P9	SELMODRAFT_111624
5		iEKPD-Sem-1211	SELMODRAFT_121036	D8SNG6	SELMODRAFT_121036
6		iEKPD-Sem-1231	SELMODRAFT_121192	D8SNH2	SELMODRAFT_121192
7		iEKPD-Sem-1210	SELMODRAFT_121210	D8SNF8	SELMODRAFT_121210
8		iEKPD-Sem-1218	SELMODRAFT_121282	D8SNG0	SELMODRAFT_121282
9		iEKPD-Sem-1229	SELMODRAFT_122967	D8SRI3	SELMODRAFT_122967
10		iEKPD-Sem-1228	SELMODRAFT_123069	D8SRJ5	SELMODRAFT_123069
11		iEKPD-Sem-1221	SELMODRAFT_123223	D8SRH8	SELMODRAFT_123223
12		iEKPD-Sem-1251	SELMODRAFT_124475	D8STJ3	SELMODRAFT_124475
13		iEKPD-Sem-1198	SELMODRAFT_125729	D8SVF2	SELMODRAFT_125729
14		iEKPD-Sem-1258	SELMODRAFT_126324	D8SW72	SELMODRAFT_126324
15		iEKPD-Sem-1192	SELMODRAFT_126751	D8SWY6	SELMODRAFT_126751
16		iEKPD-Sem-1263	SELMODRAFT_129025	D8T018	SELMODRAFT_129025
17		iEKPD-Sem-1206	SELMODRAFT_129286	D8T0Q9	SELMODRAFT_129286
18		iEKPD-Sem-1242	SELMODRAFT_131171	D8T3J4	SELMODRAFT_131171
19		iEKPD-Sem-1197	SELMODRAFT_131302	D8T3V9	SELMODRAFT_131302
20		iEKPD-Sem-1236	SELMODRAFT_131706	D8T4R8	SELMODRAFT_131706
21		iEKPD-Sem-1214	SELMODRAFT_133639	D8T7B5	SELMODRAFT_133639
22		iEKPD-Sem-1247	SELMODRAFT_135380	D8TAC3	SELMODRAFT_135380
23		iEKPD-Sem-1230	SELMODRAFT_137174	D8TD50	SELMODRAFT_137174
24		iEKPD-Sem-1249	SELMODRAFT_137904	D8TEC3	SELMODRAFT_137904
25		iEKPD-Sem-1248	SELMODRAFT_137927	D8TEC6	SELMODRAFT_137927
26		iEKPD-Sem-1178	SELMODRAFT_173599	D8RRN6	SELMODRAFT_173599
27		iEKPD-Sem-1239	SELMODRAFT_79490	D8QY70	SELMODRAFT_174307
28		iEKPD-Sem-1212	SELMODRAFT_23521	D8T2E6	SELMODRAFT_23521
29		iEKPD-Sem-1215	SELMODRAFT_32861	D8RXJ3	SELMODRAFT_32861
30		iEKPD-Sem-1276	SELMODRAFT_36536	D8T795	SELMODRAFT_36536
31		iEKPD-Sem-1233	SELMODRAFT_402603	D8QR72	SELMODRAFT_402603
32		iEKPD-Sem-1918	SELMODRAFT_405568	D8QZ05	SELMODRAFT_405568
33		iEKPD-Sem-1269	SELMODRAFT_405868	D8QZY1	SELMODRAFT_405868
34		iEKPD-Sem-1273	SELMODRAFT_408265	D8R7R4	SELMODRAFT_408265
35		iEKPD-Sem-1917	SELMODRAFT_411029	D8RHS4	SELMODRAFT_411029
36		iEKPD-Sem-1216	SELMODRAFT_411169	D8RGS7	SELMODRAFT_411169
37		iEKPD-Sem-1234	SELMODRAFT_411177	D8RGT8	SELMODRAFT_411177
38		iEKPD-Sem-1246	SELMODRAFT_415083	D8RUY8	SELMODRAFT_415083
39		iEKPD-Sem-1237	SELMODRAFT_415093	D8RV00	SELMODRAFT_415093
40		iEKPD-Sem-1266	SELMODRAFT_415773	D8RX72	SELMODRAFT_415773
41		iEKPD-Sem-1241	SELMODRAFT_417095	D8S1C3	SELMODRAFT_417095
42		iEKPD-Sem-1235	SELMODRAFT_417101	D8S1D0	SELMODRAFT_417101
43		iEKPD-Sem-1915	SELMODRAFT_418187	D8S4Y5	SELMODRAFT_418187
44		iEKPD-Sem-1265	SELMODRAFT_418315	D8S5B5	SELMODRAFT_418315
45		iEKPD-Sem-1268	SELMODRAFT_418336	D8S5E0	SELMODRAFT_418336
46		iEKPD-Sem-1227	SELMODRAFT_418345	D8S5F1	SELMODRAFT_418345
47		iEKPD-Sem-1223	SELMODRAFT_418692	D8S6U9	SELMODRAFT_418692
48		iEKPD-Sem-1224	SELMODRAFT_423987	D8SNF6	SELMODRAFT_423987
49		iEKPD-Sem-1254	SELMODRAFT_424001	D8SNH0	SELMODRAFT_424001
50		iEKPD-Sem-1222	SELMODRAFT_424005	D8SNH4	SELMODRAFT_424005
51		iEKPD-Sem-1256	SELMODRAFT_424076	D8SNQ7	SELMODRAFT_424076
52		iEKPD-Sem-1271	SELMODRAFT_424529	D8SQ72	SELMODRAFT_424529
53		iEKPD-Sem-1240	SELMODRAFT_425135	D8SS46	SELMODRAFT_425135
54		iEKPD-Sem-1267	SELMODRAFT_426476	D8SWH5	SELMODRAFT_426476
55		iEKPD-Sem-1253	SELMODRAFT_427569	D8T009	SELMODRAFT_427569
56		iEKPD-Sem-1259	SELMODRAFT_4374	D8SP37	SELMODRAFT_4374
57		iEKPD-Sem-1916	SELMODRAFT_440109	D8RA55	SELMODRAFT_440109
58		iEKPD-Sem-1270	SELMODRAFT_442163	D8RRA7	SELMODRAFT_442163
59		iEKPD-Sem-1283	SELMODRAFT_443858	D8S4Y2	SELMODRAFT_443858
60		iEKPD-Sem-1262	SELMODRAFT_4536	D8RIM4	SELMODRAFT_4536
61		iEKPD-Sem-1225	SELMODRAFT_48489	D8SNG2	SELMODRAFT_48489
62		iEKPD-Sem-1220	SELMODRAFT_5469	D8SRI0	SELMODRAFT_5469
63		iEKPD-Sem-1238	SELMODRAFT_5484	D8SHQ6	SELMODRAFT_5484
64		iEKPD-Sem-1209	SELMODRAFT_5501	D8S8N5	SELMODRAFT_5501
65		iEKPD-Sem-1204	SELMODRAFT_5502	D8SQ07	SELMODRAFT_5502
66		iEKPD-Sem-1205	SELMODRAFT_5512	D8SJM3	SELMODRAFT_5512
67		iEKPD-Sem-1217	SELMODRAFT_5836	D8SNE4	SELMODRAFT_5836
68		iEKPD-Sem-1250	SELMODRAFT_58587	D8SES1	SELMODRAFT_58587
69		iEKPD-Sem-1219	SELMODRAFT_5868	D8SNG4	SELMODRAFT_5868
70		iEKPD-Sem-1208	SELMODRAFT_5873	D8RRX2	SELMODRAFT_5873
71		iEKPD-Sem-1260	SELMODRAFT_5876	D8RG76	SELMODRAFT_5876
72		iEKPD-Sem-1232	SELMODRAFT_67516	D8RAI6	SELMODRAFT_67516
73		iEKPD-Sem-1255	SELMODRAFT_7432	D8RG82	SELMODRAFT_7432
74		iEKPD-Sem-1245	SELMODRAFT_75138	D8QR26	SELMODRAFT_75138
75		iEKPD-Sem-1195	SELMODRAFT_77112	D8QTN0	SELMODRAFT_77112
76		iEKPD-Sem-1243	SELMODRAFT_85337	D8R502	SELMODRAFT_85337
77		iEKPD-Sem-1244	SELMODRAFT_87588	D8R7V9	SELMODRAFT_87588