※ FCP family introduction

    FCP/SCP phosphatase belongs to a family of phosphatase which uses an Asp nucleophile for catalysis. FCP/SCP is characterized by its phosphatase activity towards the CTD of the largest subunit of RNA polymerase II (1). At least seven members have been identified in human genome and FCP/SCP phosphatases share a conserved catalytic signature, which is known as DXDXT/V (2). Family member FCP1 is conserved among all eukaryotes and plays an important role in cell survival in budding and fission yeasts. SCP1 preferentially dephosphorylates Ser5 in CTD domain of RNA polymerase II and plays a role in the regulation of gene expression by controlling the transition from initiation/capping to processive transcript elongation (3). In addition, SCP1 also acts as a key regulator that functions in silencing neuronal gene expression (4).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Moorhead, G.B., Trinkle-Mulcahy, L. and Ulke-Lemee, A. (2007) Emerging roles of nuclear protein phosphatases. Nat Rev Mol Cell Biol, 8, 234-244. PMID: 17318227
3. Yeo, M., Lin, P.S., Dahmus, M.E. and Gill, G.N. (2003) A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. J Biol Chem, 278, 26078-26085. PMID: 12721286
4. Yeo, M., Lee, S.K., Lee, B., Ruiz, E.C., Pfaff, S.L. and Gill, G.N. (2005) Small CTD phosphatases function in silencing neuronal gene expression. Science, 307, 596-600. PMID: 15681389

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sei-1390	Si010082m.g	K3Y791	LOC101753734
2		iEKPD-Sei-1384	Si022349m.g	K3Z730	LOC101757531
3		iEKPD-Sei-1383	Si022326m.g	K3Z706	LOC101757535
4		iEKPD-Sei-1857	Si019173m.g	K3YY23	LOC101757759
5		iEKPD-Sei-1389	Si019418m.g	K3YYR2	LOC101758169
6		iEKPD-Sei-1386	Si030027m.g	K3ZTU7	LOC101758718
7		iEKPD-Sei-1380	Si001362m.g	K3XHJ1	LOC101762870
8		iEKPD-Sei-1376	Si022793m.g	K3Z8C3	LOC101764027
9		iEKPD-Sei-1400	Si000422m.g	K3XEV5	LOC101764359
10		iEKPD-Sei-1375	Si002329m.g	K3XKA6	LOC101765036
11		iEKPD-Sei-1379	Si002037m.g	K3XJG4	LOC101776114
12		iEKPD-Sei-1377	Si001967m.g	K3XJ94	LOC101776229
13		iEKPD-Sei-1373	Si001474m.g	K3XHU7	LOC101777600
14		iEKPD-Sei-1361	Si016243m.g	K3YPQ1	LOC101778165
15		iEKPD-Sei-1395	Si009341m.g	K3Y553	LOC101785183
16		iEKPD-Sei-1858	Si021686m.g	K3Z568	LOC101786822
17		iEKPD-Sei-1859	Si025879m.g	A0A0Q3UZE7	SETIT_0258791mg