Ailuropoda melanoleuca      Asp-Based PTP/EYA


※ EYA family introduction

    Eyes absent protein phosphatase (EYA) belongs to a family of phosphatase which uses an Asp nucleophile for catalysis. Eye protein is characterized by its highly conserved C-terminal domain Eye domain(ED) ~270 amino acids, which also contains a phosphatase catalytic domain. Mammals EYA family contains four members, known as, EYA1-4 and Drosophila has only one gene (1).

Reference
1. Jemc, J. and Rebay, I. (2007) The eyes absent family of phosphotyrosine phosphatases: properties and roles in developmental regulation of transcription. Annu Rev Biochem, 76, 513-538. PMID: 17341163


There are 4 genes.  Reviewed (0 or Unreviewed (4

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Aim-0508
ENSAMEG00000010748.1
G1LW75
EYA1
2
iEKPD-Aim-0502
ENSAMEG00000011164.1
G1LXK1
EYA3
3
iEKPD-Aim-0528
ENSAMEG00000015924.1
G1MBV3
EYA4
4
iEKPD-Aim-0524
ENSAMEG00000013348.1
G1M449
LOC100482877