Canis familiaris      Asp-Based PTP/EYA


※ EYA family introduction

    Eyes absent protein phosphatase (EYA) belongs to a family of phosphatase which uses an Asp nucleophile for catalysis. Eye protein is characterized by its highly conserved C-terminal domain Eye domain(ED) ~270 amino acids, which also contains a phosphatase catalytic domain. Mammals EYA family contains four members, known as, EYA1-4 and Drosophila has only one gene (1).

Reference
1. Jemc, J. and Rebay, I. (2007) The eyes absent family of phosphotyrosine phosphatases: properties and roles in developmental regulation of transcription. Annu Rev Biochem, 76, 513-538. PMID: 17341163


There are 4 genes.  Reviewed (0 or Unreviewed (4

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Caf-0515
ENSCAFG00000007894.3
F1Q2Y0
EYA1
2
iEKPD-Caf-0510
ENSCAFG00000010677.3
E2R0A2
EYA2
3
iEKPD-Caf-0519
ENSCAFG00000011935.3
E2QU03
EYA3
4
iEKPD-Caf-0520
ENSCAFG00000000196.4
F1PAW0
EYA4