Otolemur garnettii      Asp-Based PTP/EYA


※ EYA family introduction

    Eyes absent protein phosphatase (EYA) belongs to a family of phosphatase which uses an Asp nucleophile for catalysis. Eye protein is characterized by its highly conserved C-terminal domain Eye domain(ED) ~270 amino acids, which also contains a phosphatase catalytic domain. Mammals EYA family contains four members, known as, EYA1-4 and Drosophila has only one gene (1).

Reference
1. Jemc, J. and Rebay, I. (2007) The eyes absent family of phosphotyrosine phosphatases: properties and roles in developmental regulation of transcription. Annu Rev Biochem, 76, 513-538. PMID: 17341163


There are 4 genes.  Reviewed (0 or Unreviewed (4

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Otg-0521
ENSOGAG00000008889.2
H0WZF3
EYA1
2
iEKPD-Otg-0515
ENSOGAG00000012691.2
H0X7I7
EYA2
3
iEKPD-Otg-0524
ENSOGAG00000015592.2
H0XDL5
EYA3
4
iEKPD-Otg-0530
ENSOGAG00000006398.2
H0WU44
EYA4