Pan troglodytes      Asp-Based PTP/EYA


※ EYA family introduction

    Eyes absent protein phosphatase (EYA) belongs to a family of phosphatase which uses an Asp nucleophile for catalysis. Eye protein is characterized by its highly conserved C-terminal domain Eye domain(ED) ~270 amino acids, which also contains a phosphatase catalytic domain. Mammals EYA family contains four members, known as, EYA1-4 and Drosophila has only one gene (1).

Reference
1. Jemc, J. and Rebay, I. (2007) The eyes absent family of phosphotyrosine phosphatases: properties and roles in developmental regulation of transcription. Annu Rev Biochem, 76, 513-538. PMID: 17341163


There are 4 genes.  Reviewed (0 or Unreviewed (4

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Pat-0570
ENSPTRG00000020337.6
H2QWA5
EYA1
2
iEKPD-Pat-0574
ENSPTRG00000013589.7
A0A2I3TTI4
EYA2
3
iEKPD-Pat-0568
ENSPTRG00000000423.6
K7D580
EYA3
4
iEKPD-Pat-0578
ENSPTRG00000018619.7
A0A2I3TVQ1
EYA4