Rattus norvegicus      Asp-Based PTP/EYA


※ EYA family introduction

    Eyes absent protein phosphatase (EYA) belongs to a family of phosphatase which uses an Asp nucleophile for catalysis. Eye protein is characterized by its highly conserved C-terminal domain Eye domain(ED) ~270 amino acids, which also contains a phosphatase catalytic domain. Mammals EYA family contains four members, known as, EYA1-4 and Drosophila has only one gene (1).

Reference
1. Jemc, J. and Rebay, I. (2007) The eyes absent family of phosphotyrosine phosphatases: properties and roles in developmental regulation of transcription. Annu Rev Biochem, 76, 513-538. PMID: 17341163


There are 4 genes.  Reviewed (0 or Unreviewed (4

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Ran-0541
ENSRNOG00000007590.7
D3ZVI5
Eya1
2
iEKPD-Ran-0532
ENSRNOG00000019203.7
E9PTJ3
Eya2
3
iEKPD-Ran-0531
ENSRNOG00000010396.7
A0A0G2JZ01
Eya3
4
iEKPD-Ran-0542
ENSRNOG00000016627.7
F1LX86
Eya4