Anolis carolinensis      Atypical/ABC1


※ ABC1 family introduction

    ABC1 kinases are family of aarF domain-containing protein kinases which belong to atypical kinase group. Five members have been identified in human genome, known as ADCK1-ADCK5. ABC1 kinases contain the conserved protein kinase motifs which is responsible for the ATP binding and phosphotransfer reaction. However, as the overall sequence is distinct with ePK domain and lack of several usual kinase motifs, they are classified into "Atypical" kinase group (1).

Reference
1. Lagier-Tourenne, C., Tazir, M., Lopez, L.C., Quinzii, C.M., Assoum, M., Drouot, N., Busso, C., Makri, S., Ali-Pacha, L., Benhassine, T. et al. (2008) ADCK3, an ancestral kinase, is mutated in a form of recessive ataxia associated with coenzyme Q10 deficiency. Am J Hum Genet, 82, 661-672. PMID: 18319074


There are 5 genes.  Reviewed (0 or Unreviewed (5

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Anc-0433
ENSACAG00000017313.3
G1KTR6
ADCK1
2
iEKPD-Anc-0261
ENSACAG00000011163.3
G1KKX0
ADCK2
3
iEKPD-Anc-0231
ENSACAG00000009746.3
H9GFJ9
ADCK5
4
iEKPD-Anc-0142
ENSACAG00000006522.3
G1KFI9
COQ8A
5
iEKPD-Anc-0328
ENSACAG00000013436.3
H9GJY9
COQ8B