Bos taurus      Atypical/ABC1


※ ABC1 family introduction

    ABC1 kinases are family of aarF domain-containing protein kinases which belong to atypical kinase group. Five members have been identified in human genome, known as ADCK1-ADCK5. ABC1 kinases contain the conserved protein kinase motifs which is responsible for the ATP binding and phosphotransfer reaction. However, as the overall sequence is distinct with ePK domain and lack of several usual kinase motifs, they are classified into "Atypical" kinase group (1).

Reference
1. Lagier-Tourenne, C., Tazir, M., Lopez, L.C., Quinzii, C.M., Assoum, M., Drouot, N., Busso, C., Makri, S., Ali-Pacha, L., Benhassine, T. et al. (2008) ADCK3, an ancestral kinase, is mutated in a form of recessive ataxia associated with coenzyme Q10 deficiency. Am J Hum Genet, 82, 661-672. PMID: 18319074


There are 5 genes.  Reviewed (1 or Unreviewed (4

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Bot-0409
ENSBTAG00000021880.5
Q29RI0
COQ8A
2
iEKPD-Bot-0225
ENSBTAG00000012106.5
F1MYG8
ADCK1
3
iEKPD-Bot-0382
ENSBTAG00000020484.5
E1BNG1
ADCK2
4
iEKPD-Bot-0201
ENSBTAG00000011064.5
F1N2C7
ADCK5
5
iEKPD-Bot-0362
ENSBTAG00000019462.5
E1B8K5
COQ8B