Chlorocebus sabaeus      Atypical/ABC1


※ ABC1 family introduction

    ABC1 kinases are family of aarF domain-containing protein kinases which belong to atypical kinase group. Five members have been identified in human genome, known as ADCK1-ADCK5. ABC1 kinases contain the conserved protein kinase motifs which is responsible for the ATP binding and phosphotransfer reaction. However, as the overall sequence is distinct with ePK domain and lack of several usual kinase motifs, they are classified into "Atypical" kinase group (1).

Reference
1. Lagier-Tourenne, C., Tazir, M., Lopez, L.C., Quinzii, C.M., Assoum, M., Drouot, N., Busso, C., Makri, S., Ali-Pacha, L., Benhassine, T. et al. (2008) ADCK3, an ancestral kinase, is mutated in a form of recessive ataxia associated with coenzyme Q10 deficiency. Am J Hum Genet, 82, 661-672. PMID: 18319074


There are 5 genes.  Reviewed (0 or Unreviewed (5

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Chs-0286
ENSCSAG00000011721.1
A0A0D9RH29
ADCK1
2
iEKPD-Chs-0193
ENSCSAG00000008230.1
A0A0D9R7A0
ADCK2
3
iEKPD-Chs-0201
ENSCSAG00000008516.1
A0A0D9R834
ADCK5
4
iEKPD-Chs-0413
ENSCSAG00000016382.1
A0A0D9RV04
COQ8A
5
iEKPD-Chs-0069
ENSCSAG00000003665.1
A0A0D9QUJ9
COQ8B