Monodelphis domestica      Atypical/ABC1


※ ABC1 family introduction

    ABC1 kinases are family of aarF domain-containing protein kinases which belong to atypical kinase group. Five members have been identified in human genome, known as ADCK1-ADCK5. ABC1 kinases contain the conserved protein kinase motifs which is responsible for the ATP binding and phosphotransfer reaction. However, as the overall sequence is distinct with ePK domain and lack of several usual kinase motifs, they are classified into "Atypical" kinase group (1).

Reference
1. Lagier-Tourenne, C., Tazir, M., Lopez, L.C., Quinzii, C.M., Assoum, M., Drouot, N., Busso, C., Makri, S., Ali-Pacha, L., Benhassine, T. et al. (2008) ADCK3, an ancestral kinase, is mutated in a form of recessive ataxia associated with coenzyme Q10 deficiency. Am J Hum Genet, 82, 661-672. PMID: 18319074


There are 5 genes.  Reviewed (0 or Unreviewed (5

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Mod-0098
ENSMODG00000005228.3
F6ZCK3
ADCK1
2
iEKPD-Mod-0281
ENSMODG00000013645.2
F6UE04
ADCK2
3
iEKPD-Mod-0225
ENSMODG00000010719.3
F7G7M7
ADCK5
4
iEKPD-Mod-0112
ENSMODG00000006151.4
F7GCL0
COQ8A
5
iEKPD-Mod-0144
ENSMODG00000007886.2
F6ZGH1
COQ8B