Pan troglodytes      Atypical/ABC1


※ ABC1 family introduction

    ABC1 kinases are family of aarF domain-containing protein kinases which belong to atypical kinase group. Five members have been identified in human genome, known as ADCK1-ADCK5. ABC1 kinases contain the conserved protein kinase motifs which is responsible for the ATP binding and phosphotransfer reaction. However, as the overall sequence is distinct with ePK domain and lack of several usual kinase motifs, they are classified into "Atypical" kinase group (1).

Reference
1. Lagier-Tourenne, C., Tazir, M., Lopez, L.C., Quinzii, C.M., Assoum, M., Drouot, N., Busso, C., Makri, S., Ali-Pacha, L., Benhassine, T. et al. (2008) ADCK3, an ancestral kinase, is mutated in a form of recessive ataxia associated with coenzyme Q10 deficiency. Am J Hum Genet, 82, 661-672. PMID: 18319074


There are 5 genes.  Reviewed (0 or Unreviewed (5

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Pat-0115
ENSPTRG00000006588.6
H2Q8Q2
ADCK1
2
iEKPD-Pat-0371
ENSPTRG00000019770.5
H2QVI1
ADCK2
3
iEKPD-Pat-0392
ENSPTRG00000020698.5
K7AMS8
ADCK5
4
iEKPD-Pat-0432
ENSPTRG00000033741.3
K7A7D2
COQ8A
5
iEKPD-Pat-0201
ENSPTRG00000011004.5
K6Z9I0
COQ8B