※ Alpha family introduction

    Alpha kinases belong to atypical kinase group and lack significant sequence similarity to ePK (1). Six members have been identified in mammals, including elongation factor 2 kinase, Dictyostelium myosin heavy chain kinases and other protein kinases. eEF-2 is involve in regulation of the global rate of protein synthesis and MHCK A is essential in regualtion of myosin assembly and disassembly. Although no detectable sequence identity between ePK and Alpha kinases has been found, the structure, sequence motifs and key amino acid residue position are very similar. The differences may impact on substrate recognition (2).

Reference
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. Drennan, D. and Ryazanov, A.G. (2004) Alpha-kinases: analysis of the family and comparison with conventional protein kinases. Prog Biophys Mol Biol, 85, 1-32. PMID: 15050379

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Caj-0353	ENSCJAG00000016211.3	F7IRA8
2		iEKPD-Caj-0076	ENSCJAG00000003780.2	F7CY57	ALPK1
3		iEKPD-Caj-0192	ENSCJAG00000009038.2	F7A4C9	EEF2K
4		iEKPD-Caj-0023	ENSCJAG00000001156.3	F7HXT4	TRPM6
5		iEKPD-Caj-0026	ENSCJAG00000001322.2	F7I2D0	TRPM7