Gallus gallus      Atypical/Alpha


※ Alpha family introduction

    Alpha kinases belong to atypical kinase group and lack significant sequence similarity to ePK (1). Six members have been identified in mammals, including elongation factor 2 kinase, Dictyostelium myosin heavy chain kinases and other protein kinases. eEF-2 is involve in regulation of the global rate of protein synthesis and MHCK A is essential in regualtion of myosin assembly and disassembly. Although no detectable sequence identity between ePK and Alpha kinases has been found, the structure, sequence motifs and key amino acid residue position are very similar. The differences may impact on substrate recognition (2).

Reference
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. Drennan, D. and Ryazanov, A.G. (2004) Alpha-kinases: analysis of the family and comparison with conventional protein kinases. Prog Biophys Mol Biol, 85, 1-32. PMID: 15050379


There are 6 genes.  Reviewed (0 or Unreviewed (6

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Gag-0101
ENSGALG00000006982.5
E1C172
2
iEKPD-Gag-0348
ENSGALG00000034846.1
A0A1D5PK34
3
iEKPD-Gag-0413
ENSGALG00000041749.2
A0A1D5PYW6
4
iEKPD-Gag-0199
ENSGALG00000012074.5
E1BQC3
ALPK1
5
iEKPD-Gag-0378
ENSGALG00000037950.1
A0A1D5PLW8
ALPK3
6
iEKPD-Gag-0281
ENSGALG00000023451.3
E1BYV3
TRPM7