※ Alpha family introduction

    Alpha kinases belong to atypical kinase group and lack significant sequence similarity to ePK (1). Six members have been identified in mammals, including elongation factor 2 kinase, Dictyostelium myosin heavy chain kinases and other protein kinases. eEF-2 is involve in regulation of the global rate of protein synthesis and MHCK A is essential in regualtion of myosin assembly and disassembly. Although no detectable sequence identity between ePK and Alpha kinases has been found, the structure, sequence motifs and key amino acid residue position are very similar. The differences may impact on substrate recognition (2).

Reference
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. Drennan, D. and Ryazanov, A.G. (2004) Alpha-kinases: analysis of the family and comparison with conventional protein kinases. Prog Biophys Mol Biol, 85, 1-32. PMID: 15050379

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Nol-0395	ENSNLEG00000016426.2	G1S360	ALPK1
2		iEKPD-Nol-0198	ENSNLEG00000008284.2	G1RA27	ALPK2
3		iEKPD-Nol-0265	ENSNLEG00000011262.2	A0A2I3H6R7	ALPK3
4		iEKPD-Nol-0286	ENSNLEG00000012136.2	A0A2I3H1F9	EEF2K
5		iEKPD-Nol-0043	ENSNLEG00000001498.2	A0A2I3GTT1	TRPM6
6		iEKPD-Nol-0162	ENSNLEG00000006292.2	G1R398	TRPM7