※ Alpha family introduction

    Alpha kinases belong to atypical kinase group and lack significant sequence similarity to ePK (1). Six members have been identified in mammals, including elongation factor 2 kinase, Dictyostelium myosin heavy chain kinases and other protein kinases. eEF-2 is involve in regulation of the global rate of protein synthesis and MHCK A is essential in regualtion of myosin assembly and disassembly. Although no detectable sequence identity between ePK and Alpha kinases has been found, the structure, sequence motifs and key amino acid residue position are very similar. The differences may impact on substrate recognition (2).

Reference
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. Drennan, D. and Ryazanov, A.G. (2004) Alpha-kinases: analysis of the family and comparison with conventional protein kinases. Prog Biophys Mol Biol, 85, 1-32. PMID: 15050379

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Ora-0344	ENSOANG00000014107.3	F6VN61
2		iEKPD-Ora-0455	ENSOANG00000030213.1	K7E7B3
3		iEKPD-Ora-0217	ENSOANG00000009300.3	F7EIE3	ALPK1
4		iEKPD-Ora-0073	ENSOANG00000003263.3	F6RRE1	EEF2K
5		iEKPD-Ora-0278	ENSOANG00000011650.3	F6S796	TRPM6