※ Alpha family introduction

    Alpha kinases belong to atypical kinase group and lack significant sequence similarity to ePK (1). Six members have been identified in mammals, including elongation factor 2 kinase, Dictyostelium myosin heavy chain kinases and other protein kinases. eEF-2 is involve in regulation of the global rate of protein synthesis and MHCK A is essential in regualtion of myosin assembly and disassembly. Although no detectable sequence identity between ePK and Alpha kinases has been found, the structure, sequence motifs and key amino acid residue position are very similar. The differences may impact on substrate recognition (2).

Reference
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. Drennan, D. and Ryazanov, A.G. (2004) Alpha-kinases: analysis of the family and comparison with conventional protein kinases. Prog Biophys Mol Biol, 85, 1-32. PMID: 15050379

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Tag-0160	ENSTGUG00000004879.1	H0Z376
2		iEKPD-Tag-0549	ENSTGUG00000017489.1	H1A4F4
3		iEKPD-Tag-0068	ENSTGUG00000001800.1	H0YU85	ALPK1
4		iEKPD-Tag-0284	ENSTGUG00000009003.1	H0ZFE2	EEF2K
5		iEKPD-Tag-0025	ENSTGUG00000000774.1	H0YR92	TRPM6
6		iEKPD-Tag-0237	ENSTGUG00000007440.1	H0ZAV3	TRPM7