※ BRD family introduction

    BRD (Bromodomain) kinases belong to atypical kinase group and the sequences of BRD kinase share no significant similarity to ePK. BRD proteins contain two bromodomain domains, they are associated with chromatin. Four members have been found in mammals (BRD2, BRD3, BRD4 and BRDT). Proteins with single bromodomain are not clearly orthologus to BRD, but may have related functions (1). Human BRD2 was first identified in Hela extracts and found to contain an autophosphorylation activity, but the activity can only be observed when purified recombinant protein was first incubated with Hela cell extract and repurified (2). BRD4 also contains the autophosphorylation and transphosphorylation activity. Bromodomain deletion will lead to the loss of activity (1).

Reference
1. Wikinome annotation: Kinase Family BRD
2. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Lua-g009	TanjilG_11674	A0A1J7HZK0	TanjilG_11674
2		iEKPD-Lua-g018	TanjilG_13033	A0A1J7G6G2	TanjilG_13033
3		iEKPD-Lua-g007	TanjilG_13627	A0A1J7GRB0	TanjilG_13627
4		iEKPD-Lua-g010	TanjilG_18279	A0A1J7H8V8	TanjilG_18279
5		iEKPD-Lua-g013	TanjilG_18640	A0A1J7HRL1	TanjilG_18640
6		iEKPD-Lua-g005	TanjilG_19677	A0A1J7GFP7	TanjilG_19677