※ BRD family introduction

    BRD (Bromodomain) kinases belong to atypical kinase group and the sequences of BRD kinase share no significant similarity to ePK. BRD proteins contain two bromodomain domains, they are associated with chromatin. Four members have been found in mammals (BRD2, BRD3, BRD4 and BRDT). Proteins with single bromodomain are not clearly orthologus to BRD, but may have related functions (1). Human BRD2 was first identified in Hela extracts and found to contain an autophosphorylation activity, but the activity can only be observed when purified recombinant protein was first incubated with Hela cell extract and repurified (2). BRD4 also contains the autophosphorylation and transphosphorylation activity. Bromodomain deletion will lead to the loss of activity (1).

Reference
1. Wikinome annotation: Kinase Family BRD
2. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Mae-g006	MANES_10G093200	A0A251JZH8	MANES_10G093200
2		iEKPD-Mae-g019	MANES_12G091200	A0A2C9UUZ0	MANES_12G091200
3		iEKPD-Mae-g024	MANES_15G116300	A0A2C9UFA8	MANES_15G116300
4		iEKPD-Mae-g030	MANES_15G157300	A0A2C9UGL4	MANES_15G157300