※ BRD family introduction

    BRD (Bromodomain) kinases belong to atypical kinase group and the sequences of BRD kinase share no significant similarity to ePK. BRD proteins contain two bromodomain domains, they are associated with chromatin. Four members have been found in mammals (BRD2, BRD3, BRD4 and BRDT). Proteins with single bromodomain are not clearly orthologus to BRD, but may have related functions (1). Human BRD2 was first identified in Hela extracts and found to contain an autophosphorylation activity, but the activity can only be observed when purified recombinant protein was first incubated with Hela cell extract and repurified (2). BRD4 also contains the autophosphorylation and transphosphorylation activity. Bromodomain deletion will lead to the loss of activity (1).

Reference
1. Wikinome annotation: Kinase Family BRD
2. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Nia-g017	A4A49_35664	A0A1J6KE29	GTE10_0
2		iEKPD-Nia-g027	A4A49_32758	A0A1J6I3H6	GTE4_1
3		iEKPD-Nia-g010	A4A49_13282	A0A1J6J3A7	GTE4_2
4		iEKPD-Nia-g009	A4A49_38824	A0A1J6JSS7	GTE7_2