※ BRD family introduction

    BRD (Bromodomain) kinases belong to atypical kinase group and the sequences of BRD kinase share no significant similarity to ePK. BRD proteins contain two bromodomain domains, they are associated with chromatin. Four members have been found in mammals (BRD2, BRD3, BRD4 and BRDT). Proteins with single bromodomain are not clearly orthologus to BRD, but may have related functions (1). Human BRD2 was first identified in Hela extracts and found to contain an autophosphorylation activity, but the activity can only be observed when purified recombinant protein was first incubated with Hela cell extract and repurified (2). BRD4 also contains the autophosphorylation and transphosphorylation activity. Bromodomain deletion will lead to the loss of activity (1).

Reference
1. Wikinome annotation: Kinase Family BRD
2. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Prp-g020	PRUPE_3G124500	A0A251PZ40	PRUPE_3G124500
2		iEKPD-Prp-g001	PRUPE_4G072500	A0A251PH04	PRUPE_4G072500
3		iEKPD-Prp-g024	PRUPE_8G075200	A0A251MUP3	PRUPE_8G075200