※ PDHK family introduction

    PDHK (Pyruvate Dehydrogenase Kinases) belong to atypical kinase group (1). PDHKs are related to histidine kinases, but the phosphorylation site is serine rather than histidine or aspartate. The structure analysis shows that PDHKs contain an N-terminal BCDHK_Adom3 domain and a C-terminal histidine kinase-like domain. The only substrate of PDHK is the E1 subunits of Pyruvate Dehydrogenase (PDH) and the phosphorylation occurs on three serine residues S230, S293 and S300 in human. PDHK is associated with diseases and can be a target for diabetes therapies (2).

Reference
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. Wikinome annotation: Kinase Family PDHK

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Glm-1662	GLYMA_14G1275001
2		iEKPD-Glm-1791	GLYMA_15G188500	Q6PP98	100785344
3		iEKPD-Glm-0981	GLYMA_09G079000	Q6PP99	100814079
4		iEKPD-Glm-1471	GLYMA_13G119800	K7LZ86	GLYMA_13G119800
5		iEKPD-Glm-1926	GLYMA_17G040500	I1MRY2	GLYMA_17G040500