Sus scrofa      Atypical/PDHK


※ PDHK family introduction

    PDHK (Pyruvate Dehydrogenase Kinases) belong to atypical kinase group (1). PDHKs are related to histidine kinases, but the phosphorylation site is serine rather than histidine or aspartate. The structure analysis shows that PDHKs contain an N-terminal BCDHK_Adom3 domain and a C-terminal histidine kinase-like domain. The only substrate of PDHK is the E1 subunits of Pyruvate Dehydrogenase (PDH) and the phosphorylation occurs on three serine residues S230, S293 and S300 in human. PDHK is associated with diseases and can be a target for diabetes therapies (2).

Reference
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. Wikinome annotation: Kinase Family PDHK


There are 5 genes.  Reviewed (0 or Unreviewed (5

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Sus-0117
ENSSSCG00000007763.3
F1RIR7
BCKDK
2
iEKPD-Sus-0271
ENSSSCG00000015958.3
F1S069
PDK1
3
iEKPD-Sus-0370
ENSSSCG00000027198.3
A0A287BSA1
PDK2
4
iEKPD-Sus-0212
ENSSSCG00000012181.4
A0A287AHT1
PDK3
5
iEKPD-Sus-0257
ENSSSCG00000015334.4
C1IHT9
PDK4