※ PDHK family introduction

    PDHK (Pyruvate Dehydrogenase Kinases) belong to atypical kinase group (1). PDHKs are related to histidine kinases, but the phosphorylation site is serine rather than histidine or aspartate. The structure analysis shows that PDHKs contain an N-terminal BCDHK_Adom3 domain and a C-terminal histidine kinase-like domain. The only substrate of PDHK is the E1 subunits of Pyruvate Dehydrogenase (PDH) and the phosphorylation occurs on three serine residues S230, S293 and S300 in human. PDHK is associated with diseases and can be a target for diabetes therapies (2).

Reference
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. Wikinome annotation: Kinase Family PDHK

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Tra-0750	TRIAE_CS42_2AS_TGACv1_112700_AA0343690	A0A1D5TL77
2		iEKPD-Tra-1077	TRIAE_CS42_2BS_TGACv1_147142_AA0478630	A0A1D5UCD2
3		iEKPD-Tra-1407	TRIAE_CS42_2DS_TGACv1_178726_AA0600180	W5C5P9
4		iEKPD-Tra-2423	TRIAE_CS42_4BL_TGACv1_320373_AA1037100	A0A1D5XG40
5		iEKPD-Tra-2602	TRIAE_CS42_4DL_TGACv1_343804_AA1139900	A0A1D5Y1F7