Zymoseptoria tritici Atypical/PGK1
※ PGK1 family introduction PGK1 is the first ATP-generating enzyme in this pathway and is highly expressed in many types of cancer (1). In the mitochondria, PGK1, acting as a protein kinase, interacts with and directly phosphorylates pyruvate dehydrogenase kinase isozyme 1 (PDHK1) at Thr338 using ATP as a phosphate donor. In addition, acetylated PGK1 interacts with Beclin1 and phosphorylates it at Ser30 to induce autophagy (2). Reference
1. Lu Z, Hunter T. (2018) Metabolic Kinases Moonlighting as Protein Kinases. Trends Biochem Sci, 43(4), 301-310. PMID: 29463470
2. Qian X, Li X, Cai Q, Zhang C, Yu Q, Jiang Y, Lee JH, Hawke D, Wang Y, Xia Y, Zheng Y, Jiang BH, Liu DX, Jiang T, Lu Z. (2017) Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy. Mol Cell, 2, 65(5),917-931. PMID: 28238651
There are 1 genes. Reviewed (0)
or Unreviewed (1) 
※ PGK1 family introduction PGK1 is the first ATP-generating enzyme in this pathway and is highly expressed in many types of cancer (1). In the mitochondria, PGK1, acting as a protein kinase, interacts with and directly phosphorylates pyruvate dehydrogenase kinase isozyme 1 (PDHK1) at Thr338 using ATP as a phosphate donor. In addition, acetylated PGK1 interacts with Beclin1 and phosphorylates it at Ser30 to induce autophagy (2). Reference
1. Lu Z, Hunter T. (2018) Metabolic Kinases Moonlighting as Protein Kinases. Trends Biochem Sci, 43(4), 301-310. PMID: 29463470
2. Qian X, Li X, Cai Q, Zhang C, Yu Q, Jiang Y, Lee JH, Hawke D, Wang Y, Xia Y, Zheng Y, Jiang BH, Liu DX, Jiang T, Lu Z. (2017) Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy. Mol Cell, 2, 65(5),917-931. PMID: 28238651
There are 1 genes. Reviewed (0)
or Unreviewed (1) | No. | Status | iEKPD ID | Ensemble Gene ID | UniProt Accession | Gene Name |
|---|---|---|---|---|---|
| 1 | |