Carlito syrichta      Atypical/RIO


※ RIO family introduction

    RIO family belongs to atypical protein kinase group, which shares little similarity of high kinase domain with ePK. RIO family is present in organisms varying from archaea to humans. All these organisms contain at least two RIO proteins, Rio1 and Rio2, but a third Rio3 group is present in multicellular eukaryotes. Rio1 and Rio2 possess kinase activity which has been demonstrated shown to be essential in S. cerevisiae and required for proper cell cycle progression and chromosome maintenance (1).

Reference
1. LaRonde-LeBlanc, N. and Wlodawer, A. (2005) The RIO kinases: an atypical protein kinase family required for ribosome biogenesis and cell cycle progression. Biochim Biophys Acta, 1754, 14-24. PMID: 16182620


There are 3 genes.  Reviewed (0 or Unreviewed (3

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Cas-0250
ENSTSYG00000011368.2
A0A1U7UIW4
RIOK1
2
iEKPD-Cas-0042
ENSTSYG00000001916.2
A0A1U7THM5
RIOK2
3
iEKPD-Cas-0005
ENSTSYG00000000142.2
A0A1U7TMA7
RIOK3