※ RIO family introduction

    RIO family belongs to atypical protein kinase group, which shares little similarity of high kinase domain with ePK. RIO family is present in organisms varying from archaea to humans. All these organisms contain at least two RIO proteins, Rio1 and Rio2, but a third Rio3 group is present in multicellular eukaryotes. Rio1 and Rio2 possess kinase activity which has been demonstrated shown to be essential in S. cerevisiae and required for proper cell cycle progression and chromosome maintenance (1).

Reference
1. LaRonde-LeBlanc, N. and Wlodawer, A. (2005) The RIO kinases: an atypical protein kinase family required for ribosome biogenesis and cell cycle progression. Biochim Biophys Acta, 1754, 14-24. PMID: 16182620

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sem-0178	SELMODRAFT_124857	D8SU31	SELMODRAFT_124857
2		iEKPD-Sem-0320	SELMODRAFT_153166	D8S7A2	SELMODRAFT_153166
3		iEKPD-Sem-0344	SELMODRAFT_159584	D8SZ27	SELMODRAFT_159584
4		iEKPD-Sem-1122	SELMODRAFT_91326	D8RDZ8	SELMODRAFT_91326