※ CAMK1 family introduction

    CAMK1 family consists of six family members in human. Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Family member CAMK1 is a monomeric 42KD enzyme distributed in most mammalian cell types. CAMK1 contains a protein kinase catalytic domain flanked by an ATP bind lobe and protein substrates bind lobe. CAMK1 keeps an inhibited state normally, with the ATP binding lobe interacting with AID domain. Active CAMK1 prefers the substrate containing a basic residue at the P-3 position and a hydrophobic residue at P-5 (1). CAMK1 acts as a key molecule in calcium-triggered CaMKK-CaMK1 signaling cascade and regulates a variety of cellular processes including transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization, neurite outgrowth and also involves in regulation of axonal extension and growth cone motility in hippocampal and cerebellar nerve cells (2).

Reference
1. Soderling, T.R. and Stull, J.T. (2001) Structure and regulation of calcium/calmodulin-dependent protein kinases. Chem Rev, 101, 2341-2352. PMID: 11749376
2. Kamata, A., Sakagami, H., Tokumitsu, H., Owada, Y., Fukunaga, K. and Kondo, H. (2007) Spatiotemporal expression of four isoforms of Ca2+/calmodulin-dependent protein kinase I in brain and its possible roles in hippocampal dendritic growth. Neurosci Res, 57, 86-97. PMID: 17056143

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sem-0907	SELMODRAFT_450100	D8S1A1	CCamK1-2
2		iEKPD-Sem-0910	SELMODRAFT_450109	D8SQ88	CPK-26
3		iEKPD-Sem-0908	SELMODRAFT_450104	D8S046	CPK1-1
4		iEKPD-Sem-0909	SELMODRAFT_450108	D8RQP3	CPK1-2
5		iEKPD-Sem-0879	SELMODRAFT_449448	D8RYX6	CPK13-1
6		iEKPD-Sem-0878	SELMODRAFT_449447	D8SV29	CPK13-2
7		iEKPD-Sem-0888	SELMODRAFT_449510	D8RF67	CPK16-1
8		iEKPD-Sem-0896	SELMODRAFT_449591	D8RHF3	CPK17-1_1
9		iEKPD-Sem-0886	SELMODRAFT_449479	D8S382	CPK17-1_2
10		iEKPD-Sem-0904	SELMODRAFT_450052	D8RKR2	CPK17-2_1
11		iEKPD-Sem-0900	SELMODRAFT_449840	D8S806	CPK17-2_2
12		iEKPD-Sem-0876	SELMODRAFT_449435	D8R7H3	CPK28
13		iEKPD-Sem-0890	SELMODRAFT_449515	D8QMQ0	CPK28-1_1
14		iEKPD-Sem-0889	SELMODRAFT_449511	D8SDC0	CPK28-1_2
15		iEKPD-Sem-0902	SELMODRAFT_450029	D8T0E9	CPK3-1
16		iEKPD-Sem-0903	SELMODRAFT_450036	D8SKD4	CPK3-2
17		iEKPD-Sem-0906	SELMODRAFT_450099	D8T7J7	CPK34
18		iEKPD-Sem-0883	SELMODRAFT_449454	D8QSK8	CPK5-1
19		iEKPD-Sem-0882	SELMODRAFT_449452	D8R1S8	CPK5-2
20		iEKPD-Sem-0880	SELMODRAFT_449449	D8S0W1	CPK7-1
21		iEKPD-Sem-0881	SELMODRAFT_449450	D8SBI8	CPK7-2
22		iEKPD-Sem-0899	SELMODRAFT_449803	D8RX05	CRK3-1
23		iEKPD-Sem-0892	SELMODRAFT_449527	D8SKH8	CRK3-2
24		iEKPD-Sem-0891	SELMODRAFT_449521	D8QPZ8	CRK5-1
25		iEKPD-Sem-0901	SELMODRAFT_449853	D8RR32	CRK5-2
26		iEKPD-Sem-0161	SELMODRAFT_121793	D8SP62	SELMODRAFT_121793
27		iEKPD-Sem-0173	SELMODRAFT_124260	D8ST68	SELMODRAFT_124260
28		iEKPD-Sem-0184	SELMODRAFT_125300	D8SUP4	SELMODRAFT_125300
29		iEKPD-Sem-0524	SELMODRAFT_25691	D8R2L7	SELMODRAFT_25691
30		iEKPD-Sem-0529	SELMODRAFT_26094	D8SM74	SELMODRAFT_26094
31		iEKPD-Sem-0595	SELMODRAFT_3410	D8R977	SELMODRAFT_3410
32		iEKPD-Sem-0832	SELMODRAFT_432384	D8TFU4	SELMODRAFT_432384
33		iEKPD-Sem-0897	SELMODRAFT_449592	D8RB08	SELMODRAFT_449592
34		iEKPD-Sem-0927	SELMODRAFT_4899	D8RPG6	SELMODRAFT_4899
35		iEKPD-Sem-0935	SELMODRAFT_5210	D8SZ54	SELMODRAFT_5210