※ CAMK1 family introduction

    CAMK1 family consists of six family members in human. Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Family member CAMK1 is a monomeric 42KD enzyme distributed in most mammalian cell types. CAMK1 contains a protein kinase catalytic domain flanked by an ATP bind lobe and protein substrates bind lobe. CAMK1 keeps an inhibited state normally, with the ATP binding lobe interacting with AID domain. Active CAMK1 prefers the substrate containing a basic residue at the P-3 position and a hydrophobic residue at P-5 (1). CAMK1 acts as a key molecule in calcium-triggered CaMKK-CaMK1 signaling cascade and regulates a variety of cellular processes including transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization, neurite outgrowth and also involves in regulation of axonal extension and growth cone motility in hippocampal and cerebellar nerve cells (2).

Reference
1. Soderling, T.R. and Stull, J.T. (2001) Structure and regulation of calcium/calmodulin-dependent protein kinases. Chem Rev, 101, 2341-2352. PMID: 11749376
2. Kamata, A., Sakagami, H., Tokumitsu, H., Owada, Y., Fukunaga, K. and Kondo, H. (2007) Spatiotemporal expression of four isoforms of Ca2+/calmodulin-dependent protein kinase I in brain and its possible roles in hippocampal dendritic growth. Neurosci Res, 57, 86-97. PMID: 17056143

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sei-1050	Si029460m.g	K3ZS81	CDPK1
2		iEKPD-Sei-0363	Si009791m.g	K3Y6F0	LOC101753182
3		iEKPD-Sei-1044	Si029399m.g	K3ZS19	LOC101754008
4		iEKPD-Sei-0366	Si009864m.g	K3Y6M3	LOC101755215
5		iEKPD-Sei-1348	Si040704m.g	K4AP56	LOC101756493
6		iEKPD-Sei-1224	Si034836m.g	K4A7I0	LOC101757290
7		iEKPD-Sei-1227	Si034852m.g	K4A7J6	LOC101758489
8		iEKPD-Sei-1218	Si034743m.g	K4A787	LOC101759574
9		iEKPD-Sei-0575	Si016899m.g	K3YRK5	LOC101760855
10		iEKPD-Sei-0725	Si021615m.g	K3Z4Z7	LOC101761711
11		iEKPD-Sei-0091	Si000940m.g	K3XGC0	LOC101763140
12		iEKPD-Sei-0142	Si003781m.g	K3XPF7	LOC101763555
13		iEKPD-Sei-0572	Si016805m.g	K3YRB1	LOC101763712
14		iEKPD-Sei-1233	Si035115m.g	K4A8A9	LOC101763898
15		iEKPD-Sei-1036	Si029300m.g	K3ZRS0	LOC101766031
16		iEKPD-Sei-0571	Si016803m.g	K3YRA9	LOC101770198
17		iEKPD-Sei-0362	Si009748m.g	K3Y6A5	LOC101771161
18		iEKPD-Sei-1047	Si029431m.g	K3ZS51	LOC101771813
19		iEKPD-Sei-0732	Si021667m.g	K3Z549	LOC101772409
20		iEKPD-Sei-1214	Si034667m.g	K4A711	LOC101772412
21		iEKPD-Sei-1231	Si035094m.g	K4A888	LOC101774986
22		iEKPD-Sei-0797	Si024765m.g	K3ZDX3	LOC101775503
23		iEKPD-Sei-1033	Si029268m.g	K3ZRN8	LOC101776696
24		iEKPD-Sei-1040	Si029343m.g	K3ZRW3	LOC101777772
25		iEKPD-Sei-0247	Si006273m.g	K3XWG5	LOC101779056
26		iEKPD-Sei-1226	Si034847m.g	K4A7J1	LOC101779715
27		iEKPD-Sei-0738	Si021787m.g	K3Z5G9	LOC101782511
28		iEKPD-Sei-0093	Si001025m.g	K3XGK4	LOC101783388
29		iEKPD-Sei-0733	Si021672m.g	K3Z554	LOC101784676
30		iEKPD-Sei-1051	Si029530m.g	K3ZSF0	LOC101784780
31		iEKPD-Sei-0242	Si006075m.g	K3XVW7	LOC101785787
32		iEKPD-Sei-0810	Si025125m.g	K3ZEX7	LOC101786432
33		iEKPD-Sei-0491	Si015574m.g	K3YMU1	SETIT_015574mg
34		iEKPD-Sei-0868	Si026320m.g	A0A0Q3UYB7	SETIT_0263201mg
35		iEKPD-Sei-0876	Si026386m.g	K3ZII4	SETIT_026386mg