※ CAMK2 family introduction

    CAMK2 (Calcium/calmodulin-dependent protein kinase type II) belongs to the CAMK group. CAMK2 is a key mediator of Ca2+ signaling. CAMK2 obtains its kinase catalytic activity fowling by binding of Ca2+/Calmodulin on its CAM binding domain. In addition, CAMK2 also undergoes multiple autoregulatory states through phosphorylation of on autoregulatory domain or CAM binding domain. Each phosphorylation state of CAMK2 can regulate related physiological targets (1). Studies show that CAMK2 is involved in sarcoplamic reticulum Ca2+ transport in skeletal muscle and function in dendritic spine and synapse formation and neuronal plasticity (2). CAMK2 also plays an important role in keep de synaptic plasticity which enables LTP and hippocampus-dependent learning (3).

Reference
1. Hudmon, A. and Schulman, H. (2002) Structure-function of the multifunctional Ca2+/calmodulin-dependent protein kinase II. Biochem J, 364, 593-611. PMID: 11931644
2. Rose, A.J., Kiens, B. and Richter, E.A. (2006) Ca2+-calmodulin-dependent protein kinase expression and signalling in skeletal muscle during exercise. J Physiol, 574, 889-903 PMID: 16690701
3. Soderling, T.R. and Stull, J.T. (2001) Structure and regulation of calcium/calmodulin-dependent protein kinases. Chem Rev, 101, 2341-2352. PMID: 11749376

  Reviewed (0)  or Unreviewed (4) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Cas-0282	ENSTSYG00000012581.2
2		iEKPD-Cas-0311	ENSTSYG00000014099.2	A0A1U7U1Q7	CAMK2A
3		iEKPD-Cas-0029	ENSTSYG00000001246.2	A0A1U7UK43	CAMK2D
4		iEKPD-Cas-0300	ENSTSYG00000013564.2	A0A1U7UMS6	CAMK2G