※ CAMKL family introduction

    CAMKL family consists of several subfamily including SNRK, QIK, BRSK, AMPK, MARK, NuaK, NIM1, HUNK, LKB, PASK, MELK and CHK1. They are classified into CAMKL family for the high similarity kinase catalytic domain. AMPK subfamily (AMP-activated protein kinase) consists of three subunits, a catalytic subunit (α) and two regulatory subunits (β and γ). Two catalytic subunits have been identified in mammals. Activation of AMPK is involved in two steps; first, AMP binds to γ-subunit, and second the phosphorylation of threonine 172 by LKB1. Activated AMPK targets a variety of substrates and participates different cellular processes including mTORC1 signaling, phosphorylation of p53 or other tumor suppressors (1). MARK subfamily (microtubule-affinity regulating kinases) consists of four members (MARK1-MARK4) in mammals cells. All isoforms contain a N-terminal header, a catalytic kinase domain, a ubiquitin-associated domain, a spacer domain and a C-terminal KA1 domain. MARKs are discovered for its ability to regulate the stability of microtubules. Studies also show that MARK has some relation with disease, such as Alzheimer's disease (2). Nuak subfamilies are AMPK related kinases. NuaK1 are stress-activated kinase which is involved in tolerance to glucose starvation. NuaK1 can induce cell-cell detachment by increasing F-actin conversion to G-actin. NuaK1 can protect cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95- activated tumor cells (3).

Reference
1. Luo, Z., Zang, M. and Guo, W. (2010) AMPK as a metabolic tumor suppressor: control of metabolism and cell growth. Future Oncol, 6, 457-470. PMID: 20222801
2. Matenia, D. and Mandelkow, E.M. (2009) The tau of MARK: a polarized view of the cytoskeleton. Trends Biochem Sci, 34, 332-342. PMID: 19559622
3. Suzuki, A., Kusakai, G., Kishimoto, A., Minegichi, Y., Ogura, T. and Esumi, H. (2003) Induction of cell-cell detachment during glucose starvation through F-actin conversion by SNARK, the fourth member of the AMP-activated protein kinase catalytic subunit family. Biochem Biophys Res Commun, 311, 156-161. PMID: 14575707

  Reviewed (0)  or Unreviewed (81) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sem-1031	SELMODRAFT_79434	C4P7R3	CIPK01
2		iEKPD-Sem-1116	SELMODRAFT_90416	C4P7R4	CIPK02
3		iEKPD-Sem-0494	SELMODRAFT_234951	C4P7R5	CIPK03
4		iEKPD-Sem-0263	SELMODRAFT_135824	C4P7R6	CIPK04
5		iEKPD-Sem-0531	SELMODRAFT_267186	C4P7R7	CIPK05
6		iEKPD-Sem-0341	SELMODRAFT_158991	D8SWP1	OST1-1
7		iEKPD-Sem-0349	SELMODRAFT_162233	D8T9J9	OST1-2
8		iEKPD-Sem-0380	SELMODRAFT_171183	D8RG24	OST2-1
9		iEKPD-Sem-0163	SELMODRAFT_122028	D8SPH9	OST2-2
10		iEKPD-Sem-0359	SELMODRAFT_164978	D8QSB6	OST3-1
11		iEKPD-Sem-0367	SELMODRAFT_167058	D8R1H8	OST3-2
12		iEKPD-Sem-0008	SELMODRAFT_101524	D8RSZ6	SELMODRAFT_101524
13		iEKPD-Sem-0077	SELMODRAFT_110333	D8S7C8	SELMODRAFT_110333
14		iEKPD-Sem-0095	SELMODRAFT_111621	D8S8Z3	SELMODRAFT_111621
15		iEKPD-Sem-0096	SELMODRAFT_111673	D8S8Z9	SELMODRAFT_111673
16		iEKPD-Sem-0104	SELMODRAFT_112499	D8SA19	SELMODRAFT_112499
17		iEKPD-Sem-0105	SELMODRAFT_112613	D8SA22	SELMODRAFT_112613
18		iEKPD-Sem-0145	SELMODRAFT_119400	D8SKL3	SELMODRAFT_119400
19		iEKPD-Sem-0152	SELMODRAFT_120104	D8SM06	SELMODRAFT_120104
20		iEKPD-Sem-0177	SELMODRAFT_124855	D8SU16	SELMODRAFT_124855
21		iEKPD-Sem-0198	SELMODRAFT_127859	D8SYF8	SELMODRAFT_127859
22		iEKPD-Sem-0208	SELMODRAFT_12938	D8RWX9	SELMODRAFT_12938
23		iEKPD-Sem-0209	SELMODRAFT_129451	D8T0Y7	SELMODRAFT_129451
24		iEKPD-Sem-0211	SELMODRAFT_129520	D8T0Z1	SELMODRAFT_129520
25		iEKPD-Sem-0232	SELMODRAFT_132147	D8T4V1	SELMODRAFT_132147
26		iEKPD-Sem-0272	SELMODRAFT_137499	D8TDQ2	SELMODRAFT_137499
27		iEKPD-Sem-0330	SELMODRAFT_15596	D8S3Y8	SELMODRAFT_15596
28		iEKPD-Sem-0331	SELMODRAFT_15599	D8R518	SELMODRAFT_15599
29		iEKPD-Sem-0335	SELMODRAFT_15648	D8RVV6	SELMODRAFT_15648
30		iEKPD-Sem-0413	SELMODRAFT_175338	D8RY51	SELMODRAFT_175338
31		iEKPD-Sem-0465	SELMODRAFT_22400	D8QXV9	SELMODRAFT_22400
32		iEKPD-Sem-0479	SELMODRAFT_232364	D8RUW4	SELMODRAFT_232364
33		iEKPD-Sem-0487	SELMODRAFT_233667	D8SCV6	SELMODRAFT_233667
34		iEKPD-Sem-0488	SELMODRAFT_234034	D8SH16	SELMODRAFT_234034
35		iEKPD-Sem-0526	SELMODRAFT_25939	D8QR73	SELMODRAFT_25939
36		iEKPD-Sem-0527	SELMODRAFT_25940	D8QR64	SELMODRAFT_25940
37		iEKPD-Sem-0528	SELMODRAFT_25945	D8R7S2	SELMODRAFT_25945
38		iEKPD-Sem-0540	SELMODRAFT_269551	D8T245	SELMODRAFT_269551
39		iEKPD-Sem-0582	SELMODRAFT_30995	D8QUF5	SELMODRAFT_30995
40		iEKPD-Sem-0606	SELMODRAFT_35928	D8R2S8	SELMODRAFT_35928
41		iEKPD-Sem-0622	SELMODRAFT_3976	D8RFV7	SELMODRAFT_3976
42		iEKPD-Sem-0625	SELMODRAFT_403833	D8QSP4	SELMODRAFT_403833
43		iEKPD-Sem-0634	SELMODRAFT_404155	D8QUF9	SELMODRAFT_404155
44		iEKPD-Sem-0635	SELMODRAFT_404156	D8QUG0	SELMODRAFT_404156
45		iEKPD-Sem-0637	SELMODRAFT_404159	D8QUG3	SELMODRAFT_404159
46		iEKPD-Sem-0639	SELMODRAFT_404167	D8QUH0	SELMODRAFT_404167
47		iEKPD-Sem-0671	SELMODRAFT_408264	D8R7R3	SELMODRAFT_408264
48		iEKPD-Sem-1065	SELMODRAFT_8334	D8RQW3	SELMODRAFT_413628
49		iEKPD-Sem-0709	SELMODRAFT_414787	D8RUM0	SELMODRAFT_414787
50		iEKPD-Sem-0719	SELMODRAFT_416642	D8RZY4	SELMODRAFT_416642
51		iEKPD-Sem-0720	SELMODRAFT_416650	D8RZZ3	SELMODRAFT_416650
52		iEKPD-Sem-0721	SELMODRAFT_416658	D8S001	SELMODRAFT_416658
53		iEKPD-Sem-0762	SELMODRAFT_424027	D8SNK1	SELMODRAFT_424027
54		iEKPD-Sem-0763	SELMODRAFT_424030	D8SNK4	SELMODRAFT_424030
55		iEKPD-Sem-0809	SELMODRAFT_430601	D8T9X3	SELMODRAFT_430601
56		iEKPD-Sem-0326	SELMODRAFT_15500	D8ST72	SELMODRAFT_446639
57		iEKPD-Sem-0929	SELMODRAFT_49458	D8T224	SELMODRAFT_49458
58		iEKPD-Sem-0930	SELMODRAFT_49513	D8SRX3	SELMODRAFT_49513
59		iEKPD-Sem-0931	SELMODRAFT_5023	D8T8S9	SELMODRAFT_5023
60		iEKPD-Sem-0932	SELMODRAFT_5036	D8SZ45	SELMODRAFT_5036
61		iEKPD-Sem-0983	SELMODRAFT_72856	D8RGZ3	SELMODRAFT_72856
62		iEKPD-Sem-0984	SELMODRAFT_72857	D8S5K3	SELMODRAFT_72857
63		iEKPD-Sem-0991	SELMODRAFT_74096	D8QQG0	SELMODRAFT_74096
64		iEKPD-Sem-0992	SELMODRAFT_7413	D8TDG1	SELMODRAFT_7413
65		iEKPD-Sem-0993	SELMODRAFT_7414	D8TDG3	SELMODRAFT_7414
66		iEKPD-Sem-1017	SELMODRAFT_78123	D8QUG9	SELMODRAFT_78123
67		iEKPD-Sem-1025	SELMODRAFT_78779	D8QVY5	SELMODRAFT_78779
68		iEKPD-Sem-1034	SELMODRAFT_79809	D8QX28	SELMODRAFT_79809
69		iEKPD-Sem-1061	SELMODRAFT_8322	D8QUH1	SELMODRAFT_8322
70		iEKPD-Sem-1062	SELMODRAFT_8329	D8R421	SELMODRAFT_8329
71		iEKPD-Sem-1063	SELMODRAFT_8331	D8TBA3	SELMODRAFT_8331
72		iEKPD-Sem-1064	SELMODRAFT_8332	D8RZZ6	SELMODRAFT_8332
73		iEKPD-Sem-1066	SELMODRAFT_8335	D8RZY8	SELMODRAFT_8335
74		iEKPD-Sem-1068	SELMODRAFT_8348	D8RY79	SELMODRAFT_8348
75		iEKPD-Sem-1070	SELMODRAFT_8351	D8RBF4	SELMODRAFT_8351
76		iEKPD-Sem-1106	SELMODRAFT_88619	D8R972	SELMODRAFT_88619
77		iEKPD-Sem-1123	SELMODRAFT_91482	D8RE13	SELMODRAFT_91482
78		iEKPD-Sem-1157	SELMODRAFT_98866	D8RQ93	SELMODRAFT_98866
79		iEKPD-Sem-1168	SELMODRAFT_99940	D8RR03	SELMODRAFT_99940
80		iEKPD-Sem-0917	SELMODRAFT_450254	D8SY37	SNRK1.2-1
81		iEKPD-Sem-0916	SELMODRAFT_450118	D8QX94	SnRK1.2-2