※ CAMKL family introduction

    CAMKL family consists of several subfamily including SNRK, QIK, BRSK, AMPK, MARK, NuaK, NIM1, HUNK, LKB, PASK, MELK and CHK1. They are classified into CAMKL family for the high similarity kinase catalytic domain. AMPK subfamily (AMP-activated protein kinase) consists of three subunits, a catalytic subunit (α) and two regulatory subunits (β and γ). Two catalytic subunits have been identified in mammals. Activation of AMPK is involved in two steps; first, AMP binds to γ-subunit, and second the phosphorylation of threonine 172 by LKB1. Activated AMPK targets a variety of substrates and participates different cellular processes including mTORC1 signaling, phosphorylation of p53 or other tumor suppressors (1). MARK subfamily (microtubule-affinity regulating kinases) consists of four members (MARK1-MARK4) in mammals cells. All isoforms contain a N-terminal header, a catalytic kinase domain, a ubiquitin-associated domain, a spacer domain and a C-terminal KA1 domain. MARKs are discovered for its ability to regulate the stability of microtubules. Studies also show that MARK has some relation with disease, such as Alzheimer's disease (2). Nuak subfamilies are AMPK related kinases. NuaK1 are stress-activated kinase which is involved in tolerance to glucose starvation. NuaK1 can induce cell-cell detachment by increasing F-actin conversion to G-actin. NuaK1 can protect cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95- activated tumor cells (3).

Reference
1. Luo, Z., Zang, M. and Guo, W. (2010) AMPK as a metabolic tumor suppressor: control of metabolism and cell growth. Future Oncol, 6, 457-470. PMID: 20222801
2. Matenia, D. and Mandelkow, E.M. (2009) The tau of MARK: a polarized view of the cytoskeleton. Trends Biochem Sci, 34, 332-342. PMID: 19559622
3. Suzuki, A., Kusakai, G., Kishimoto, A., Minegichi, Y., Ogura, T. and Esumi, H. (2003) Induction of cell-cell detachment during glucose starvation through F-actin conversion by SNARK, the fourth member of the AMP-activated protein kinase catalytic subunit family. Biochem Biophys Res Commun, 311, 156-161. PMID: 14575707

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sei-0873	Si026369m.g	K3ZIG7	CIPK1
2		iEKPD-Sei-0373	Si010116m.g	K3Y7C5	CIPK2
3		iEKPD-Sei-1281	Si036283m.g	K4ABM6	LOC101752819
4		iEKPD-Sei-0869	Si026322m.g	K3ZIC0	LOC101753202
5		iEKPD-Sei-1065	Si029846m.g	K3ZTB6	LOC101754539
6		iEKPD-Sei-0763	Si022358m.g	K3Z738	LOC101756577
7		iEKPD-Sei-0092	Si000965m.g	K3XGE5	LOC101757197
8		iEKPD-Sei-0256	Si006409m.g	K3XWV1	LOC101757697
9		iEKPD-Sei-0584	Si017133m.g	K3YS89	LOC101757993
10		iEKPD-Sei-1063	Si029827m.g	K3ZT97	LOC101758021
11		iEKPD-Sei-1286	Si036309m.g	K4ABQ2	LOC101758084
12		iEKPD-Sei-0094	Si001041m.g	K3XGM0	LOC101758543
13		iEKPD-Sei-1254	Si035675m.g	K4A9W9	LOC101762701
14		iEKPD-Sei-0372	Si010093m.g	K3Y7A2	LOC101763048
15		iEKPD-Sei-1290	Si036531m.g	K4ACC4	LOC101763654
16		iEKPD-Sei-0132	Si001965m.g	K3XJ92	LOC101764618
17		iEKPD-Sei-0768	Si022448m.g	K3Z7C8	LOC101765115
18		iEKPD-Sei-1253	Si035646m.g	K4A9U0	LOC101765549
19		iEKPD-Sei-0745	Si021946m.g	K3Z5X8	LOC101767148
20		iEKPD-Sei-1261	Si035799m.g	K4AA92	LOC101768376
21		iEKPD-Sei-0106	Si001288m.g	K3XHB7	LOC101768415
22		iEKPD-Sei-0374	Si010128m.g	K3Y7D7	LOC101769028
23		iEKPD-Sei-1064	Si029831m.g	K3ZTA1	LOC101769428
24		iEKPD-Sei-0752	Si022090m.g	K3Z6C1	LOC101769723
25		iEKPD-Sei-1241	Si035270m.g	K4A8R4	LOC101769880
26		iEKPD-Sei-0723	Si021606m.g	K3Z4Y8	LOC101770809
27		iEKPD-Sei-0376	Si010180m.g	K3Y7I9	LOC101771684
28		iEKPD-Sei-0764	Si022378m.g	K3Z758	LOC101772001
29		iEKPD-Sei-1271	Si036041m.g	K4AAY4	LOC101775125
30		iEKPD-Sei-0200	Si005356m.g	K3XTU9	LOC101776111
31		iEKPD-Sei-0616	Si018012m.g	K3YUR6	LOC101778169
32		iEKPD-Sei-0614	Si017915m.g	K3YUG9	LOC101779241
33		iEKPD-Sei-0250	Si006337m.g	K3XWM9	LOC101779470
34		iEKPD-Sei-1070	Si029903m.g	K3ZTH3	LOC101781023
35		iEKPD-Sei-1061	Si029821m.g	K3ZT91	LOC101781426
36		iEKPD-Sei-0111	Si001346m.g	K3XHH5	LOC101781756
37		iEKPD-Sei-1081	Si030417m.g	K3ZUY6	LOC101782227
38		iEKPD-Sei-0115	Si001423m.g	K3XHQ1	LOC101782586
39		iEKPD-Sei-0464	Si013759m.g	K3YHP1	LOC101783685
40		iEKPD-Sei-0462	Si013722m.g	K3YHK4	LOC101784626
41		iEKPD-Sei-0751	Si022074m.g	K3Z6A5	LOC101784956
42		iEKPD-Sei-0740	Si021825m.g	K3Z5L0	LOC101785071
43		iEKPD-Sei-1057	Si029714m.g	K3ZSY4	LOC101786516
44		iEKPD-Sei-0601	Si017369m.g	K3YSX4	LOC101786757
45		iEKPD-Sei-0750	Si021995m.g	K3Z627	LOC101786950
46		iEKPD-Sei-1340	Si040049m.g	K4AMB1	LOC101786974
47		iEKPD-Sei-0098	Si001185m.g	K3XH14	SETIT_001185mg
48		iEKPD-Sei-0114	Si001420m.g	K3XHP8	SETIT_001420mg
49		iEKPD-Sei-0642	Si019716m.g	K3YZK6	SETIT_019716mg
50		iEKPD-Sei-0759	Si022225m.g	K3Z6Q6	SETIT_022225mg
51		iEKPD-Sei-0776	Si024166m.g	K3ZC92	SETIT_024166mg
52		iEKPD-Sei-0875	Si026385m.g	K3ZII3	SETIT_026385mg
53		iEKPD-Sei-0883	Si026521m.g	K3ZIW8	SETIT_026521mg
54		iEKPD-Sei-1350	Si040877m.g	K4APM9	SETIT_040877mg