※ PIM family introduction

    PIM consists of three members, PIM-1, PIM-2 and PIM-3. Sequence analysis shows that PIM-1 and PIM-2 share a sequence identity of 61%, whereas PIM-1 and PIM-3 are 77%. PIM kinases play an important role in cancer. PIM-1 and PIM-2 transgenic mice overexpression these genes have been observed to develop lymphomas. In addition, PIM-1 is over expressed in c-myc transgene driven prostate tumors in mice. In human, PIM-1 and PIM-2 are involved in prostate cancer development. Studies show that PIM-3 is over expressed in colorectal, pancreatic and hepatocellular carcinoma. The mechanisms that PIMs implicated in cancer have been reported that PIMs act as key regulator in several major proliferative and survival signaling pathways or influence the activity of specific cell cycle molecules and changes in gene expression (1).

Reference
1. Isaac, M., Siu, A. and Jongstra, J. (2011) The oncogenic PIM kinase family regulates drug resistance through multiple mechanisms. Drug Resist Updat, 14, 203-211. PMID: 21601509

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Tag-0020	ENSTGUG00000000506.1	H0YQF7
2		iEKPD-Tag-0021	ENSTGUG00000000507.1	H0YQG1
3		iEKPD-Tag-0032	ENSTGUG00000000954.1	H0YRR9
4		iEKPD-Tag-0116	ENSTGUG00000003363.1	H0YYU6
5		iEKPD-Tag-0162	ENSTGUG00000004886.1	H0Z398
6		iEKPD-Tag-0397	ENSTGUG00000013680.1	H0ZTZ5
7		iEKPD-Tag-0399	ENSTGUG00000013703.1	H0ZU11
8		iEKPD-Tag-0402	ENSTGUG00000013726.1	H0ZU46
9		iEKPD-Tag-0403	ENSTGUG00000013728.1	H0ZU31
10		iEKPD-Tag-0405	ENSTGUG00000013802.1	H0ZUB0
11		iEKPD-Tag-0406	ENSTGUG00000013807.1	H0ZUB3
12		iEKPD-Tag-0418	ENSTGUG00000014338.1	H0ZVR6
13		iEKPD-Tag-0424	ENSTGUG00000014394.1	H0ZVY4
14		iEKPD-Tag-0425	ENSTGUG00000014408.1	H0ZVZ1
15		iEKPD-Tag-0429	ENSTGUG00000014587.1	H0ZWF4
16		iEKPD-Tag-0434	ENSTGUG00000014652.1	H0ZWM2
17		iEKPD-Tag-0436	ENSTGUG00000014682.1	H0ZWQ4
18		iEKPD-Tag-0438	ENSTGUG00000014699.1	H0ZWQ9
19		iEKPD-Tag-0445	ENSTGUG00000014802.1	H0ZX10
20		iEKPD-Tag-0446	ENSTGUG00000014882.1	H0ZX91
21		iEKPD-Tag-0455	ENSTGUG00000015047.1	H0ZXQ5
22		iEKPD-Tag-0459	ENSTGUG00000015140.1	H0ZXY5
23		iEKPD-Tag-0460	ENSTGUG00000015196.1	H0ZY42
24		iEKPD-Tag-0461	ENSTGUG00000015232.1	H0ZY94
25		iEKPD-Tag-0467	ENSTGUG00000015282.1	H0ZYC0
26		iEKPD-Tag-0468	ENSTGUG00000015296.1	H0ZYE4
27		iEKPD-Tag-0475	ENSTGUG00000015552.1	H0ZZ50
28		iEKPD-Tag-0477	ENSTGUG00000015583.1	H0ZZ62
29		iEKPD-Tag-0480	ENSTGUG00000015813.1	H0ZZT9
30		iEKPD-Tag-0487	ENSTGUG00000015970.1	H1A081
31		iEKPD-Tag-0488	ENSTGUG00000015977.1	H1A092
32		iEKPD-Tag-0492	ENSTGUG00000016151.1	H1A0Q9
33		iEKPD-Tag-0494	ENSTGUG00000016198.1	H1A0W4
34		iEKPD-Tag-0503	ENSTGUG00000016445.1	H1A1I6
35		iEKPD-Tag-0506	ENSTGUG00000016467.1	H1A1L0
36		iEKPD-Tag-0507	ENSTGUG00000016468.1	H1A1K5
37		iEKPD-Tag-0508	ENSTGUG00000016485.1	H1A1N7
38		iEKPD-Tag-0511	ENSTGUG00000016503.1	H1A1P4
39		iEKPD-Tag-0516	ENSTGUG00000016725.1	H1A2B4
40		iEKPD-Tag-0519	ENSTGUG00000016751.1	H1A2E4
41		iEKPD-Tag-0522	ENSTGUG00000016845.1	H1A2M4
42		iEKPD-Tag-0526	ENSTGUG00000017009.1	H1A332
43		iEKPD-Tag-0533	ENSTGUG00000017104.1	H1A3C8
44		iEKPD-Tag-0543	ENSTGUG00000017234.1	H1A3P9
45		iEKPD-Tag-0426	ENSTGUG00000014454.1	H0ZW36	LOC100219237
46		iEKPD-Tag-0452	ENSTGUG00000014957.1	H0ZXH3	LOC100221669
47		iEKPD-Tag-0540	ENSTGUG00000017212.1	H1A3M8	LOC100222216
48		iEKPD-Tag-0464	ENSTGUG00000015242.1	H0ZY91	LOC100223219
49		iEKPD-Tag-0413	ENSTGUG00000014083.1	H0ZV39	LOC100226018
50		iEKPD-Tag-0529	ENSTGUG00000017083.1	H1A3B2	LOC100226112
51		iEKPD-Tag-0514	ENSTGUG00000016626.1	H1A218	LOC100232144
52		iEKPD-Tag-0130	ENSTGUG00000003897.1	H0Z0C9	PIM3