※ PIM family introduction

    PIM consists of three members, PIM-1, PIM-2 and PIM-3. Sequence analysis shows that PIM-1 and PIM-2 share a sequence identity of 61%, whereas PIM-1 and PIM-3 are 77%. PIM kinases play an important role in cancer. PIM-1 and PIM-2 transgenic mice overexpression these genes have been observed to develop lymphomas. In addition, PIM-1 is over expressed in c-myc transgene driven prostate tumors in mice. In human, PIM-1 and PIM-2 are involved in prostate cancer development. Studies show that PIM-3 is over expressed in colorectal, pancreatic and hepatocellular carcinoma. The mechanisms that PIMs implicated in cancer have been reported that PIMs act as key regulator in several major proliferative and survival signaling pathways or influence the activity of specific cell cycle molecules and changes in gene expression (1).

Reference
1. Isaac, M., Siu, A. and Jongstra, J. (2011) The oncogenic PIM kinase family regulates drug resistance through multiple mechanisms. Drug Resist Updat, 14, 203-211. PMID: 21601509

  Reviewed (0)  or Unreviewed (15) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Tar-0121	ENSTRUG00000004086.1
2		iEKPD-Tar-0217	ENSTRUG00000006707.1	H2SVP5
3		iEKPD-Tar-0271	ENSTRUG00000008369.1	H2T8G4
4		iEKPD-Tar-0374	ENSTRUG00000011244.1	H2TUN7
5		iEKPD-Tar-0439	ENSTRUG00000013320.1	H2UAF5
6		iEKPD-Tar-0489	ENSTRUG00000015203.1	H2UPH2
7		iEKPD-Tar-0550	ENSTRUG00000016947.1	H2V2G8
8		iEKPD-Tar-0561	ENSTRUG00000017154.1	H2V409
9		iEKPD-Tar-0144	ENSTRUG00000004643.1	H2SF57	LOC101066855
10		iEKPD-Tar-0236	ENSTRUG00000007285.1	H2SZX5	LOC101074494
11		iEKPD-Tar-0170	ENSTRUG00000005490.1	H2SLA4	pim1
12		iEKPD-Tar-0291	ENSTRUG00000008867.1	H2TC97	PIM1
13		iEKPD-Tar-0372	ENSTRUG00000011201.1	H2TUC0	PIM1
14		iEKPD-Tar-0527	ENSTRUG00000016377.1	H2UY38	PIM1
15		iEKPD-Tar-0042	ENSTRUG00000001489.1	H2RTG1	pim3