※ RAD53 family introduction

    RAD53, also known as Checkpoint kinase 2, is a key kinase which is required in checkpoint-mediated cell cycle related processes. When damage response occurred, Mec1 protein is recruited to bind DNA and triggers the downstream signal cascade. Rad9 is activated via phosphorylation by Mec1 and as a result RAD53 binds to Rad9 with the phospho-binding domain FHA and undergoes autophosphorylation events which are important on activation of Rad53. Activated RAD53 amplifies the original signals and triggers the downstream events of checkpoint activation including cell cycle delay, DNA repair, replication fork stabilization and fork restart processes (1).

Reference
1. Branzei, D. and Foiani, M. (2006) The Rad53 signal transduction pathway: Replication fork stabilization, DNA repair, and adaptation. Exp Cell Res, 312, 2654-2659. PMID: 16859682

  Reviewed (0)  or Unreviewed (6) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Beb-0355	BB8028_0002g16200	J5K8P9	BBA_00126
2		iEKPD-Beb-0015	BB8028_0001g07070	J5JW12	BBA_01858
3		iEKPD-Beb-0098	BB8028_0004g08000	J5K089	BBA_03491
4		iEKPD-Beb-0356	BB8028_0003g11750	J5JR58	BBA_06016
5		iEKPD-Beb-0161	BB8028_0008g01910	J4KLW7	BBA_08129
6		iEKPD-Beb-0034	BB8028_0001g16740	J5J7A4	BBA_08735