※ RAD53 family introduction

    RAD53, also known as Checkpoint kinase 2, is a key kinase which is required in checkpoint-mediated cell cycle related processes. When damage response occurred, Mec1 protein is recruited to bind DNA and triggers the downstream signal cascade. Rad9 is activated via phosphorylation by Mec1 and as a result RAD53 binds to Rad9 with the phospho-binding domain FHA and undergoes autophosphorylation events which are important on activation of Rad53. Activated RAD53 amplifies the original signals and triggers the downstream events of checkpoint activation including cell cycle delay, DNA repair, replication fork stabilization and fork restart processes (1).

Reference
1. Branzei, D. and Foiani, M. (2006) The Rad53 signal transduction pathway: Replication fork stabilization, DNA repair, and adaptation. Exp Cell Res, 312, 2654-2659. PMID: 16859682

  Reviewed (0)  or Unreviewed (8) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Gas-0350	GGTG_01579	J3NJZ7	GGTG_01579
2		iEKPD-Gas-0020	GGTG_01898	J3NKV7	GGTG_01898
3		iEKPD-Gas-0351	GGTG_02901	J3NNP4	GGTG_02901
4		iEKPD-Gas-0054	GGTG_04740	J3NTZ1	GGTG_04740
5		iEKPD-Gas-0134	GGTG_12157	J3PF78	GGTG_12157
6		iEKPD-Gas-0143	GGTG_13085	J3PHV4	GGTG_13085
7		iEKPD-Gas-0147	GGTG_13416	J3PIT6	GGTG_13416
8		iEKPD-Gas-0150	GGTG_13690	J3PJK4	GGTG_13690