※ RAD53 family introduction

    RAD53, also known as Checkpoint kinase 2, is a key kinase which is required in checkpoint-mediated cell cycle related processes. When damage response occurred, Mec1 protein is recruited to bind DNA and triggers the downstream signal cascade. Rad9 is activated via phosphorylation by Mec1 and as a result RAD53 binds to Rad9 with the phospho-binding domain FHA and undergoes autophosphorylation events which are important on activation of Rad53. Activated RAD53 amplifies the original signals and triggers the downstream events of checkpoint activation including cell cycle delay, DNA repair, replication fork stabilization and fork restart processes (1).

Reference
1. Branzei, D. and Foiani, M. (2006) The Rad53 signal transduction pathway: Replication fork stabilization, DNA repair, and adaptation. Exp Cell Res, 312, 2654-2659. PMID: 16859682

  Reviewed (0)  or Unreviewed (10) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sem-0084	SELMODRAFT_110675	D8S7A5	SELMODRAFT_110675
2		iEKPD-Sem-0603	SELMODRAFT_35259	D8T1G6	SELMODRAFT_35259
3		iEKPD-Sem-0632	SELMODRAFT_404148	D8QUF3	SELMODRAFT_404148
4		iEKPD-Sem-0655	SELMODRAFT_4059	D8RA03	SELMODRAFT_4059
5		iEKPD-Sem-0690	SELMODRAFT_410738	D8RFQ4	SELMODRAFT_410738
6		iEKPD-Sem-0713	SELMODRAFT_4154	D8RFR2	SELMODRAFT_4154
7		iEKPD-Sem-0765	SELMODRAFT_424201	D8SP51	SELMODRAFT_424201
8		iEKPD-Sem-0766	SELMODRAFT_424204	D8SP54	SELMODRAFT_424204
9		iEKPD-Sem-0808	SELMODRAFT_430503	D8T9L9	SELMODRAFT_430503
10		iEKPD-Sem-0928	SELMODRAFT_4917	D8R417	SELMODRAFT_4917