※ RAD53 family introduction

    RAD53, also known as Checkpoint kinase 2, is a key kinase which is required in checkpoint-mediated cell cycle related processes. When damage response occurred, Mec1 protein is recruited to bind DNA and triggers the downstream signal cascade. Rad9 is activated via phosphorylation by Mec1 and as a result RAD53 binds to Rad9 with the phospho-binding domain FHA and undergoes autophosphorylation events which are important on activation of Rad53. Activated RAD53 amplifies the original signals and triggers the downstream events of checkpoint activation including cell cycle delay, DNA repair, replication fork stabilization and fork restart processes (1).

Reference
1. Branzei, D. and Foiani, M. (2006) The Rad53 signal transduction pathway: Replication fork stabilization, DNA repair, and adaptation. Exp Cell Res, 312, 2654-2659. PMID: 16859682

  Reviewed (0)  or Unreviewed (5) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Tum-0020	GSTUM_00002286001	D5G6V2	GSTUM_00002286001
2		iEKPD-Tum-0037	GSTUM_00004260001	D5G5B7	GSTUM_00004260001
3		iEKPD-Tum-0073	GSTUM_00007046001	D5GFS1	GSTUM_00007046001
4		iEKPD-Tum-0272	GSTUM_00011396001	D5GNP2	GSTUM_00011396001
5		iEKPD-Tum-0273	GSTUM_00011944001	D5GPN2	GSTUM_00011944001