※ RAD53 family introduction

    RAD53, also known as Checkpoint kinase 2, is a key kinase which is required in checkpoint-mediated cell cycle related processes. When damage response occurred, Mec1 protein is recruited to bind DNA and triggers the downstream signal cascade. Rad9 is activated via phosphorylation by Mec1 and as a result RAD53 binds to Rad9 with the phospho-binding domain FHA and undergoes autophosphorylation events which are important on activation of Rad53. Activated RAD53 amplifies the original signals and triggers the downstream events of checkpoint activation including cell cycle delay, DNA repair, replication fork stabilization and fork restart processes (1).

Reference
1. Branzei, D. and Foiani, M. (2006) The Rad53 signal transduction pathway: Replication fork stabilization, DNA repair, and adaptation. Exp Cell Res, 312, 2654-2659. PMID: 16859682

  Reviewed (0)  or Unreviewed (6) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Zyt-0309	Mycgr3G20459	F9WYA6	MYCGRDRAFT_20459
2		iEKPD-Zyt-0050	Mycgr3G44536	F9XF57	MYCGRDRAFT_44536
3		iEKPD-Zyt-0053	Mycgr3G45453	F9XF56	MYCGRDRAFT_45453
4		iEKPD-Zyt-0054	Mycgr3G45539	F9XF55	MYCGRDRAFT_45539
5		iEKPD-Zyt-0027	Mycgr3G27394	F9XIN3	MYCGRDRAFT_45763
6		iEKPD-Zyt-0310	Mycgr3G74088	F9XG05	MYCGRDRAFT_74088